About Enhancer
| Enhancer ID: | E_00067 |
| Species: | Homo sapiens |
| Position : | chr2:121926020-121926640   |
| Year: | 2025 |
| Title: | Bidirectional epigenetic editing reveals hierarchies in gene regulation |
| Genome Build: | hg38 |
| Enhancer Type: | Enhancer |
| Condition: | Normal |
| Disease Name: | -- |
| PMID: | 38760566 |
| MONDO: | |
| Tissue: | Peripheral blood |
| Tissue Ontology ID: | UBERON:0000178 |
| Cell Source: | primary human memory CD4 T cell |
| CVCL ID: | |
| Cell Type: | memory CD4-positive T cell |
| Cell Ontology ID: | CL:0000897 |
| Experiment Type: | CRISPRi loss-of-function, CRISPRa gain-of-function, ATAC-qPCR chromatin accessibility validation |
| High Throughput Method: | ATAC-seq, H3K27ac ChIP-seq, H3K4me1 ChIP-seq, scRNA-seq, Perturb-seq |
| Low Throughput Method: | gRNA enrichment screening, intracellular cytokine flow cytometry, RT-qPCR, ATAC-qPCR, primary human T cell lentiviral transduction |
About Target Gene
| Target gene : | IL2 |
About TF
| TF name : | JUND |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| JUND | AP-1 transcription factor network | pid | 71 |
| JUND | ATF-2 transcription factor network | pid | 59 |
| JUND | EGFR1 | netpath | 475 |
| JUND | Inflammation mediated by chemokine and cytokine signaling pathway | panther | 189 |
| JUND | PDGFR-beta signaling pathway | pid | 125 |
| JUND | TGF-beta signaling pathway | panther | 88 |
| JUND | TGF_beta_Receptor | netpath | 220 |
| JUND | Validated transcriptional targets of AP1 family members Fra1 and Fra2 | pid | 37 |
| JUND | MAPK signaling pathway | kegg | 264 |
| JUND | Hs_Apoptosis-related_network_due_to_altered_Notch3_in_ovarian_cancer_WP2864_79278 | wikipathways | 51 |
| JUND | Hs_VEGFA-VEGFR2_Signaling_Pathway_WP3888_90000 | wikipathways | 153 |
| JUND | Hs_Oncostatin_M_Signaling_Pathway_WP2374_73668 | wikipathways | 44 |
| JUND | Hs_EGF-EGFR_Signaling_Pathway_WP437_79266 | wikipathways | 107 |
Enhancer Associated Network
Overlapping Enhancers (hg38)
1 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_00066 | chr2:121926020-121926640 | Peripheral blood | T lymphoblast | -- |
Expression of Target Genes for the Enhancer