About Enhancer
| Enhancer ID: | E_00067 |
| Species: | Mus musculus |
| Position : | chr12:85490344-85493924   |
| Year: | 2016 |
| Title: | Stimulus-specific combinatorial functionality of neuronal c-fos enhancers. |
| Genome Build: | mm10 |
| Enhancer Type: | Enhancer |
| Condition: | Normal |
| PMID: | 26595656 |
| Tissue: | brain |
| Tissue Ontology ID: | UBERON:0000955 |
| Cell Source: | primary mouse cortical neurons |
| Cell Type: | neuron |
| Cell Ontology ID: | CL:0000540 |
| Experiment Type: | Stimulus-responsive enhancer assay; enhancer-promoter interaction; endogenous enhancer perturbation |
| High Throughput Method: | RNA-seq; ChIP-seq and chromatin-state integration |
| Low Throughput Method: | Luciferase reporter assay; enhancer RNA RT-qPCR; 3C; CRISPRi; MEF2A ChIP; transcription-factor perturbation |
About Target Gene
| Target gene : | Fos |
About TF
| TF name : | Mef2a |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| Mef2a | CDO in myogenesis | reactome | 29 |
| Mef2a | ERK/MAPK targets | reactome | 17 |
| Mef2a | Signaling mediated by p38-alpha and p38-beta | pid | 35 |
| Mef2a | TGF_beta_Receptor | netpath | 220 |
| Mef2a | Hs_p38_MAPK_Signaling_Pathway_WP400_72084 | wikipathways | 28 |
Enhancer Associated Network
Expression of Target Genes for the Enhancer