About Enhancer
| Enhancer ID: | E_00068 |
| Species: | Homo sapiens |
| Position : | chr2:121928130-121928780   |
| Year: | 2025 |
| Title: | Bidirectional epigenetic editing reveals hierarchies in gene regulation |
| Genome Build: | hg38 |
| Enhancer Type: | Enhancer |
| Condition: | Normal |
| Disease Name: | -- |
| PMID: | 38760566 |
| MONDO: | |
| Tissue: | Peripheral blood |
| Tissue Ontology ID: | UBERON:0000178 |
| Cell Source: | Jurkat E6-1 |
| CVCL ID: | CVCL_0367 |
| Cell Type: | T lymphoblast |
| Cell Ontology ID: | CL:0002419 |
| Experiment Type: | CRISPRi loss-of-function, CRISPRa gain-of-function |
| High Throughput Method: | ATAC-seq, H3K27ac ChIP-seq, H3K4me1 ChIP-seq, scRNA-seq, Perturb-seq |
| Low Throughput Method: | gRNA enrichment screening, intracellular cytokine flow cytometry, RT-qPCR |
About Target Gene
| Target gene : | IL2 |
About TF
| TF name : | BATF3 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| BATF3 | Calcineurin-regulated NFAT-dependent transcription in lymphocytes | pid | 50 |
| BATF3 | Calcium signaling in the CD4+ TCR pathway | pid | 29 |
Enhancer Associated Network
Overlapping Enhancers (hg38)
No overlapping enhancers found in hg38 at this locus.
Expression of Target Genes for the Enhancer