About Enhancer
| Enhancer ID: | E_00068 |
| Species: | Mus musculus |
| Position : | chr11:32145028-32146147   |
| Year: | 2016 |
| Title: | Genetic dissection of the ζ±-globin super-enhancer in vivo. |
| Genome Build: | mm9 |
| Enhancer Type: | Enhancer |
| Condition: | Normal |
| PMID: | 27376235 |
| Tissue: | liver |
| Tissue Ontology ID: | UBERON:0002107 |
| Cell Source: | primary E12.5 fetal-liver erythroid cells |
| Cell Type: | erythroblast |
| Cell Ontology ID: | CL:0000765 |
| Experiment Type: | Enhancer activity assay; TF binding assay; Endogenous enhancer deletion assay; Chromatin interaction assay; Chromatin accessibility assay; In vivo functional validation |
| High Throughput Method: | DNase-seq; GATA1/TAL1/KLF1/NFE2/MED1 ChIP-seq; ATAC-seq; nascent RNA-seq; NG Capture-C |
| Low Throughput Method: | Targeted enhancer deletion mouse model; NanoString expression analysis; stable transgenic LacZ reporter assay; chick embryo enhancer reporter assay; Southern blot; sequencing; hematologic phenotyping; In vivo phenotyping |
About Target Gene
| Target gene : | Hba-a1 |
About TF
| TF name : | Gata1 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| Gata1 | C-MYB transcription factor network | pid | 87 |
| Gata1 | Factors involved in megakaryocyte development and platelet production | reactome | 111 |
| Gata1 | IL3 | netpath | 84 |
| Gata1 | Notch-mediated HES/HEY network | pid | 48 |
| Gata1 | p73 transcription factor network | pid | 80 |
| Gata1 | Signaling events mediated by HDAC Class I | pid | 89 |
| Gata1 | Signaling events mediated by HDAC Class II | pid | 58 |
Enhancer Associated Network
Overlapping Enhancers (mm9)
44 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_00069 | chr11:32145028-32146147 | liver | erythroblast | NA |
| E_00070 | chr11:32145028-32146147 | liver | erythroblast | NA |
| E_00071 | chr11:32145028-32146147 | liver | erythroblast | NA |
| E_00072 | chr11:32145028-32146147 | liver | erythroblast | NA |
| E_00073 | chr11:32145028-32146147 | liver | erythroblast | NA |
| E_00074 | chr11:32145028-32146147 | liver | erythroblast | NA |
| E_00075 | chr11:32145028-32146147 | liver | erythroblast | NA |
| E_00084 | chr11:32145028-32146147 | liver | erythroblast | NA |
| E_00085 | chr11:32145028-32146147 | liver | erythroblast | NA |
| E_00086 | chr11:32145028-32146147 | liver | erythroblast | NA |
| E_00087 | chr11:32145028-32146147 | liver | erythroblast | NA |
| E_00088 | chr11:32145028-32146147 | liver | erythroblast | NA |
| E_00089 | chr11:32145028-32146147 | liver | erythroblast | NA |
| E_00090 | chr11:32145028-32146147 | liver | erythroblast | NA |
| E_00091 | chr11:32145028-32146147 | liver | erythroblast | NA |
| E_00205 | chr11:32145028-32146147 | liver | erythroblast | NA |
| E_00206 | chr11:32145028-32146147 | liver | erythroblast | NA |
| E_00207 | chr11:32145028-32146147 | liver | erythroblast | NA |
| E_00208 | chr11:32145028-32146147 | liver | erythroblast | NA |
| E_00209 | chr11:32145028-32146147 | liver | erythroblast | NA |
| E_00210 | chr11:32145028-32146147 | liver | erythroblast | NA |
| E_00211 | chr11:32145028-32146147 | liver | erythroblast | NA |
| E_00212 | chr11:32145028-32146147 | liver | erythroblast | NA |
| E_00442 | chr11:32145028-32146147 | blood | erythroid cell | NA |
| E_00443 | chr11:32145028-32146147 | blood | erythroid cell | NA |
| E_00444 | chr11:32145028-32146147 | blood | erythroid cell | NA |
| E_00445 | chr11:32145028-32146147 | blood | erythroid cell | NA |
| E_02543 | chr11:32145028-32146147 | NA | primitive erythroid lineage cell | NA |
| E_02544 | chr11:32145028-32146147 | NA | primitive erythroid lineage cell | NA |
| E_02545 | chr11:32145028-32146147 | NA | primitive erythroid lineage cell | NA |
| E_02546 | chr11:32145028-32146147 | NA | primitive erythroid lineage cell | NA |
| E_02547 | chr11:32145028-32146147 | NA | primitive erythroid lineage cell | NA |
| E_02548 | chr11:32145028-32146147 | NA | primitive erythroid lineage cell | NA |
| E_02549 | chr11:32145028-32146147 | NA | primitive erythroid lineage cell | NA |
| E_02550 | chr11:32145028-32146147 | NA | primitive erythroid lineage cell | NA |
| E_03320 | chr11:32145028-32146147 | liver | erythroid cell | NA |
| E_03474 | chr11:32145028-32146147 | spleen | erythroblast | NA |
| E_03475 | chr11:32145028-32146147 | spleen | erythroblast | NA |
| E_03476 | chr11:32145028-32146147 | spleen | erythroblast | NA |
| E_03477 | chr11:32145028-32146147 | spleen | erythroblast | NA |
| E_03478 | chr11:32145028-32146147 | spleen | erythroblast | NA |
| E_03479 | chr11:32145028-32146147 | spleen | erythroblast | NA |
| E_02494 | chr11:32145540-32169344 | NA | primitive erythroid lineage cell | NA |
| E_02495 | chr11:32145540-32169344 | NA | primitive erythroid lineage cell | NA |
Expression of Target Genes for the Enhancer