About Enhancer
| Enhancer ID: | E_00069 |
| Species: | Homo sapiens |
| Position : | chr12:68541220-68541790   |
| Year: | 2025 |
| Title: | Bidirectional epigenetic editing reveals hierarchies in gene regulation |
| Genome Build: | hg38 |
| Enhancer Type: | Enhancer |
| Condition: | Normal |
| Disease Name: | -- |
| PMID: | 38760566 |
| MONDO: | |
| Tissue: | Peripheral blood |
| Tissue Ontology ID: | UBERON:0000178 |
| Cell Source: | Jurkat E6-1 |
| CVCL ID: | CVCL_0367 |
| Cell Type: | T lymphoblast |
| Cell Ontology ID: | CL:0002419 |
| Experiment Type: | CRISPRi loss-of-function, CRISPRa gain-of-function |
| High Throughput Method: | ATAC-seq, H3K27ac ChIP-seq, scRNA-seq |
| Low Throughput Method: | gRNA enrichment screening, intracellular cytokine flow cytometry, RT-qPCR |
About Target Gene
| Target gene : | IFNG |
About TF
| TF name : | ETV6 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| ETV6 | ERK cascade ( FGF8 signaling (Mouse) ) | inoh | 17 |
| ETV6 | ERK cascade ( FGF8 signaling (Xenopus) ) | inoh | 17 |
| ETV6 | FGF8 signaling pathway(Mouse) ( FGF8 signaling (Mouse) ) | inoh | 20 |
| ETV6 | FGF8 signaling pathway(Xenopus) ( FGF8 signaling (Xenopus) ) | inoh | 18 |
| ETV6 | MAPK signaling pathway - fly | kegg | 16 |
| ETV6 | Dorso-ventral axis formation | kegg | 25 |
Enhancer Associated Network
Overlapping Enhancers (hg38)
No overlapping enhancers found in hg38 at this locus.
Expression of Target Genes for the Enhancer