About Enhancer
| Enhancer ID: | E_00070 |
| Species: | Homo sapiens |
| Position : | chr13:73958961-73960160   |
| Year: | 2025 |
| Title: | Characterization of cis-regulatory elements and functional variants in colorectal cancer using epigenomics and CRISPRi screenings |
| Genome Build: | hg19 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | Colorectal adenocarcinoma |
| PMID: | 40854986 |
| MONDO: | MONDO:0003420 |
| Tissue: | Colon |
| Tissue Ontology ID: | UBERON:0001155 |
| Cell Source: | HCT116 |
| CVCL ID: | CVCL_0291 |
| Cell Type: | colorectal carcinoma cell line |
| Cell Ontology ID: | CL:0001071 |
| Experiment Type: | Dual-luciferase reporter assay, CRISPR-Cas9 base editing, CRISPRi silencing, 3C chromatin capture, ChIP-qPCR |
| High Throughput Method: | ATAC-seq, H3K27ac ChIP-seq, Hi-C, RNA-seq, ABC model prediction, GWAS summary statistics |
| Low Throughput Method: | qRT-PCR, EMSA supershift assay, DNase I footprinting, cell proliferation assay, colony formation assay, mouse xenograft tumor assay |
About Target Gene
| Target gene : | PIBF1 |
About TF
| TF name : | FOXP1 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|
Enhancer Associated Network
Overlapping Enhancers (hg19)
7 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_00071 | chr13:73958961-73960160 | Colon | colorectal carcinoma cell line | Colorectal adenocarcinoma |
| E_00072 | chr13:73958961-73960160 | Colon | colorectal carcinoma cell line | Colorectal adenocarcinoma |
| E_00073 | chr13:73958961-73960160 | Colon | colorectal carcinoma cell line | Colorectal adenocarcinoma |
| E_00074 | chr13:73958961-73960160 | Colon | colorectal carcinoma cell line | Colorectal adenocarcinoma |
| E_00075 | chr13:73958961-73960160 | Colon | colorectal carcinoma cell line | Colorectal adenocarcinoma |
| E_00076 | chr13:73958961-73960160 | Colon | colorectal carcinoma cell line | Colorectal adenocarcinoma |
| E_00077 | chr13:73958961-73960160 | Colon | colorectal carcinoma cell line | Colorectal adenocarcinoma |
Expression of Target Genes for the Enhancer