About Enhancer
| Enhancer ID: | E_00081 |
| Species: | Mus musculus |
| Position : | chr11:32150550-32151858   |
| Year: | 2016 |
| Title: | Genetic dissection of the ζ±-globin super-enhancer in vivo. |
| Genome Build: | mm9 |
| Enhancer Type: | Enhancer |
| Condition: | Normal |
| PMID: | 27376235 |
| Tissue: | liver |
| Tissue Ontology ID: | UBERON:0002107 |
| Cell Source: | primary E12.5 fetal-liver erythroid cells |
| Cell Type: | erythroblast |
| Cell Ontology ID: | CL:0000765 |
| Experiment Type: | Enhancer activity assay; TF binding assay; Endogenous enhancer deletion assay; Chromatin interaction assay; Chromatin accessibility assay; In vivo functional validation |
| High Throughput Method: | DNase-seq; GATA1/TAL1/KLF1/NFE2/MED1 ChIP-seq; ATAC-seq; nascent RNA-seq; NG Capture-C |
| Low Throughput Method: | Targeted enhancer deletion mouse model; NanoString expression analysis; stable transgenic LacZ reporter assay; chick embryo enhancer reporter assay; Southern blot; sequencing; hematologic phenotyping; In vivo phenotyping |
About Target Gene
| Target gene : | Hba-a2 |
About TF
| TF name : | Nfe2 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| Nfe2 | Factors involved in megakaryocyte development and platelet production | reactome | 111 |
Enhancer Associated Network
Overlapping Enhancers (mm9)
44 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_02494 | chr11:32145540-32169344 | NA | primitive erythroid lineage cell | NA |
| E_02495 | chr11:32145540-32169344 | NA | primitive erythroid lineage cell | NA |
| E_00076 | chr11:32150550-32151858 | liver | erythroblast | NA |
| E_00077 | chr11:32150550-32151858 | liver | erythroblast | NA |
| E_00078 | chr11:32150550-32151858 | liver | erythroblast | NA |
| E_00079 | chr11:32150550-32151858 | liver | erythroblast | NA |
| E_00080 | chr11:32150550-32151858 | liver | erythroblast | NA |
| E_00082 | chr11:32150550-32151858 | liver | erythroblast | NA |
| E_00083 | chr11:32150550-32151858 | liver | erythroblast | NA |
| E_00092 | chr11:32150550-32151858 | liver | erythroblast | NA |
| E_00093 | chr11:32150550-32151858 | liver | erythroblast | NA |
| E_00094 | chr11:32150550-32151858 | liver | erythroblast | NA |
| E_00095 | chr11:32150550-32151858 | liver | erythroblast | NA |
| E_00096 | chr11:32150550-32151858 | liver | erythroblast | NA |
| E_00097 | chr11:32150550-32151858 | liver | erythroblast | NA |
| E_00098 | chr11:32150550-32151858 | liver | erythroblast | NA |
| E_00099 | chr11:32150550-32151858 | liver | erythroblast | NA |
| E_00213 | chr11:32150550-32151858 | liver | erythroblast | NA |
| E_00214 | chr11:32150550-32151858 | liver | erythroblast | NA |
| E_00215 | chr11:32150550-32151858 | liver | erythroblast | NA |
| E_00216 | chr11:32150550-32151858 | liver | erythroblast | NA |
| E_00217 | chr11:32150550-32151858 | liver | erythroblast | NA |
| E_00218 | chr11:32150550-32151858 | liver | erythroblast | NA |
| E_00219 | chr11:32150550-32151858 | liver | erythroblast | NA |
| E_00220 | chr11:32150550-32151858 | liver | erythroblast | NA |
| E_00446 | chr11:32150550-32151858 | blood | erythroid cell | NA |
| E_00447 | chr11:32150550-32151858 | blood | erythroid cell | NA |
| E_00448 | chr11:32150550-32151858 | blood | erythroid cell | NA |
| E_00449 | chr11:32150550-32151858 | blood | erythroid cell | NA |
| E_02551 | chr11:32150550-32151858 | NA | primitive erythroid lineage cell | NA |
| E_02552 | chr11:32150550-32151858 | NA | primitive erythroid lineage cell | NA |
| E_02553 | chr11:32150550-32151858 | NA | primitive erythroid lineage cell | NA |
| E_02554 | chr11:32150550-32151858 | NA | primitive erythroid lineage cell | NA |
| E_02555 | chr11:32150550-32151858 | NA | primitive erythroid lineage cell | NA |
| E_02556 | chr11:32150550-32151858 | NA | primitive erythroid lineage cell | NA |
| E_02557 | chr11:32150550-32151858 | NA | primitive erythroid lineage cell | NA |
| E_02558 | chr11:32150550-32151858 | NA | primitive erythroid lineage cell | NA |
| E_03313 | chr11:32150550-32151858 | liver | erythroid cell | NA |
| E_03480 | chr11:32150550-32151858 | spleen | erythroblast | NA |
| E_03481 | chr11:32150550-32151858 | spleen | erythroblast | NA |
| E_03482 | chr11:32150550-32151858 | spleen | erythroblast | NA |
| E_03483 | chr11:32150550-32151858 | spleen | erythroblast | NA |
| E_03484 | chr11:32150550-32151858 | spleen | erythroblast | NA |
| E_03485 | chr11:32150550-32151858 | spleen | erythroblast | NA |
Expression of Target Genes for the Enhancer