About Enhancer
| Enhancer ID: | E_00084 |
| Species: | Homo sapiens |
| Position : | chr20:63680793-63682109   |
| Year: | 2025 |
| Title: | Systematic decoding of functional enhancer connectomes and risk variants in human glioma |
| Genome Build: | hg38 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | Glioblastoma multiforme |
| PMID: | 40830415 |
| MONDO: | MONDO:0001628 |
| Tissue: | Brain |
| Tissue Ontology ID: | UBERON:0000955 |
| Cell Source: | U251 |
| CVCL ID: | CVCL_0021 |
| Cell Type: | glioma cell line |
| Cell Ontology ID: | CL:0000917 |
| Experiment Type: | Dual-luciferase reporter assay, CRISPR-Cas9 full locus knockout, CRISPR base editing, 3C-qPCR, ChIP-qPCR, dCas9-KRAB CRISPRi |
| High Throughput Method: | H3K27ac HiChIP, H3K27ac ChIP-seq, ATAC-seq, RNA-seq, pooled CRISPRi screening, GWAS variant analysis |
| Low Throughput Method: | qRT-PCR, cell proliferation MTT assay, colony formation assay, glioma sphere formation assay, mouse intracranial xenograft, Sanger sequencing |
About Target Gene
| Target gene : | SOX18 |
About TF
| TF name : | MEIS1 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| MEIS1 | Activation of anterior HOX genes in hindbrain development during early embryogenesis | reactome | 120 |
Enhancer Associated Network
Overlapping Enhancers (hg38)
13 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_01308 | chr20:63680288-63681605 | Brain | glioblastoma cell | glioblastoma |
| E_01309 | chr20:63680288-63681605 | Brain | glioblastoma cell | glioblastoma |
| E_01310 | chr20:63680288-63681605 | Brain | glioblastoma cell | glioblastoma |
| E_00056 | chr20:63680793-63682109 | Brain | glioma cell line | Glioblastoma multiforme |
| E_00057 | chr20:63680793-63682109 | Brain | glioma cell line | Glioblastoma multiforme |
| E_00058 | chr20:63680793-63682109 | Brain | glioma cell line | Glioblastoma multiforme |
| E_00085 | chr20:63680793-63682109 | Brain | glioma cell line | Glioblastoma multiforme |
| E_00086 | chr20:63680793-63682109 | Brain | glioma cell line | Glioblastoma multiforme |
| E_00087 | chr20:63680793-63682109 | Brain | glioma cell line | Glioblastoma multiforme |
| E_00119 | chr20:63680793-63682109 | Brain | glioma cell line | Glioblastoma multiforme |
| E_00120 | chr20:63680793-63682109 | Brain | glioma cell line | Glioblastoma multiforme |
| E_00121 | chr20:63680793-63682109 | Brain | glioma cell line | Glioblastoma multiforme |
| E_00122 | chr20:63680793-63682109 | Brain | glioma cell line | Glioblastoma multiforme |
Expression of Target Genes for the Enhancer