About Enhancer
| Enhancer ID: | E_00094 |
| Species: | Homo sapiens |
| Position : | chr3:111274001-111275000   |
| Year: | 2025 |
| Title: | Enhancer activation from transposable elements in extrachromosomal DNA |
| Genome Build: | hg19 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | Colorectal adenocarcinoma |
| PMID: | 41120733 |
| MONDO: | MONDO:0003420 |
| Tissue: | Colon |
| Tissue Ontology ID: | UBERON:0001155 |
| Cell Source: | COLO320DM |
| CVCL ID: | CVCL_0219 |
| Cell Type: | colorectal carcinoma cell line |
| Cell Ontology ID: | CL:0001071 |
| Experiment Type: | Dual-luciferase reporter assay, dCas9-KRAB CRISPRi loss-of-function, Hi-C chromatin contact mapping, ORCA single-cell chromatin imaging |
| High Throughput Method: | H3K27ac ChIP-seq, ATAC-seq, Nanopore long-read WGS, RNA-seq, pooled CRISPRi screening |
| Low Throughput Method: | NanoLuc dual luciferase detection, CRISPR-CATCH PFGE isolation, RT-qPCR, RNA-FISH, cell proliferation MTT assay |
About Target Gene
| Target gene : | MYC |
About TF
| TF name : |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|
Enhancer Associated Network
Expression of Target Genes for the Enhancer