About Enhancer
| Enhancer ID: | E_00102 |
| Species: | Homo sapiens |
| Position : | chr21:43361800-43362620   |
| Year: | 2021 |
| Title: | Enhancer release and retargeting activates disease-susceptibility genes |
| Genome Build: | hg19 |
| Enhancer Type: | Enhancer |
| Condition: | Normal |
| Disease Name: | -- |
| PMID: | 34040254 |
| MONDO: | |
| Tissue: | Mammary gland |
| Tissue Ontology ID: | UBERON:0001911 |
| Cell Source: | MCF-7 |
| CVCL ID: | CVCL_0031 |
| Cell Type: | estrogen-responsive breast epithelial cell |
| Cell Ontology ID: | CL:0001070 |
| Experiment Type: | CRISPR-Cas9 locus deletion, 4C-seq chromatin interaction, ChIP-qPCR, siRNA cohesin knockdown |
| High Throughput Method: | GRO-seq, CTCF ChIA-PET, H3K4me3/H3K4me1 ChIP-seq |
| Low Throughput Method: | RT-qPCR, clonal cell line generation, chromatin immunoprecipitation |
About Target Gene
| Target gene : | TFF1 |
About TF
| TF name : | FOXA1 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| FOXA1 | AndrogenReceptor | netpath | 167 |
| FOXA1 | Direct p53 effectors | pid | 141 |
| FOXA1 | FOXA1 transcription factor network | pid | 45 |
| FOXA1 | FOXA2 and FOXA3 transcription factor networks | pid | 45 |
| FOXA1 | Hs_Endoderm_Differentiation_WP2853_88152 | wikipathways | 62 |
Enhancer Associated Network
Overlapping Enhancers (hg19)
1 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_00101 | chr21:43361800-43362620 | Mammary gland | estrogen-responsive breast epithelial cell | -- |
Expression of Target Genes for the Enhancer