About Enhancer
| Enhancer ID: | E_00114 |
| Species: | Mus musculus |
| Position : | chr11:32165011-32165922   |
| Year: | 2016 |
| Title: | Genetic dissection of the ζ±-globin super-enhancer in vivo. |
| Genome Build: | mm9 |
| Enhancer Type: | Enhancer |
| Condition: | Normal |
| PMID: | 27376235 |
| Tissue: | liver |
| Tissue Ontology ID: | UBERON:0002107 |
| Cell Source: | primary E12.5 fetal-liver erythroid cells |
| Cell Type: | erythroblast |
| Cell Ontology ID: | CL:0000765 |
| Experiment Type: | Super-enhancer constituent functional assay; TF binding assay; Endogenous cis-element deletion assay; In vivo functional validation |
| High Throughput Method: | DNase-seq; GATA1/NFE2/MED1 ChIP-seq; ATAC-seq; nascent RNA-seq; NG Capture-C |
| Low Throughput Method: | Targeted Rm deletion mouse model; NanoString; chick embryo reporter assay; stable transgenic LacZ reporter assay; In vivo phenotyping |
About Target Gene
| Target gene : | Hba-a1 |
About TF
| TF name : | Gata1 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| Gata1 | C-MYB transcription factor network | pid | 87 |
| Gata1 | Factors involved in megakaryocyte development and platelet production | reactome | 111 |
| Gata1 | IL3 | netpath | 84 |
| Gata1 | Notch-mediated HES/HEY network | pid | 48 |
| Gata1 | p73 transcription factor network | pid | 80 |
| Gata1 | Signaling events mediated by HDAC Class I | pid | 89 |
| Gata1 | Signaling events mediated by HDAC Class II | pid | 58 |
Enhancer Associated Network
Overlapping Enhancers (mm9)
16 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_02494 | chr11:32145540-32169344 | NA | primitive erythroid lineage cell | NA |
| E_02495 | chr11:32145540-32169344 | NA | primitive erythroid lineage cell | NA |
| E_00112 | chr11:32165011-32165922 | liver | erythroblast | NA |
| E_00113 | chr11:32165011-32165922 | liver | erythroblast | NA |
| E_00115 | chr11:32165011-32165922 | liver | erythroblast | NA |
| E_00116 | chr11:32165011-32165922 | liver | erythroblast | NA |
| E_00117 | chr11:32165011-32165922 | liver | erythroblast | NA |
| E_00118 | chr11:32165011-32165922 | liver | erythroblast | NA |
| E_00119 | chr11:32165011-32165922 | liver | erythroblast | NA |
| E_03322 | chr11:32165011-32165922 | liver | erythroid cell | NA |
| E_03490 | chr11:32165011-32165922 | spleen | erythroblast | NA |
| E_03491 | chr11:32165011-32165922 | spleen | erythroblast | NA |
| E_03492 | chr11:32165011-32165922 | spleen | erythroblast | NA |
| E_03493 | chr11:32165011-32165922 | spleen | erythroblast | NA |
| E_03494 | chr11:32165011-32165922 | spleen | erythroblast | NA |
| E_03495 | chr11:32165011-32165922 | spleen | erythroblast | NA |
Expression of Target Genes for the Enhancer