About Enhancer
| Enhancer ID: | E_00126 |
| Species: | Homo sapiens |
| Position : | chr2:18910338-18911438   |
| Year: | 2025 |
| Title: | Systematic decoding of functional enhancer connectomes and risk variants in human glioma |
| Genome Build: | hg38 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | Glioblastoma multiforme |
| PMID: | 40830415 |
| MONDO: | MONDO:0001628 |
| Tissue: | Brain |
| Tissue Ontology ID: | UBERON:0000955 |
| Cell Source: | U251 |
| CVCL ID: | CVCL_0021 |
| Cell Type: | glioma cell line |
| Cell Ontology ID: | CL:0000917 |
| Experiment Type: | dCas9-KRAB CRISPRi, HiChIP chromatin looping validation |
| High Throughput Method: | H3K27ac HiChIP, H3K27ac ChIP-seq, RNA-seq, pooled CRISPRi screening |
| Low Throughput Method: | RT-qPCR, MTT cell proliferation assay |
About Target Gene
| Target gene : | SDC1 |
About TF
| TF name : |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|
Enhancer Associated Network
Overlapping Enhancers (hg38)
11 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_00061 | chr2:18910338-18911438 | Brain | glioma cell line | Glioblastoma multiforme |
| E_00062 | chr2:18910338-18911438 | Brain | glioma cell line | Glioblastoma multiforme |
| E_00063 | chr2:18910338-18911438 | Brain | glioma cell line | Glioblastoma multiforme |
| E_00064 | chr2:18910338-18911438 | Brain | glioma cell line | Glioblastoma multiforme |
| E_00090 | chr2:18910338-18911438 | Brain | glioma cell line | Glioblastoma multiforme |
| E_00091 | chr2:18910338-18911438 | Brain | glioma cell line | Glioblastoma multiforme |
| E_00092 | chr2:18910338-18911438 | Brain | glioma cell line | Glioblastoma multiforme |
| E_00093 | chr2:18910338-18911438 | Brain | glioma cell line | Glioblastoma multiforme |
| E_00125 | chr2:18910338-18911438 | Brain | glioma cell line | Glioblastoma multiforme |
| E_00127 | chr2:18910338-18911438 | Brain | glioma cell line | Glioblastoma multiforme |
| E_00128 | chr2:18910338-18911438 | Brain | glioma cell line | Glioblastoma multiforme |
Expression of Target Genes for the Enhancer