About Enhancer
| Enhancer ID: | E_00131 |
| Species: | Mus musculus |
| Position : | chr11:32168783-32169689   |
| Year: | 2016 |
| Title: | Genetic dissection of the ζ±-globin super-enhancer in vivo. |
| Genome Build: | mm9 |
| Enhancer Type: | Enhancer |
| Condition: | Normal |
| PMID: | 27376235 |
| Tissue: | liver |
| Tissue Ontology ID: | UBERON:0002107 |
| Cell Source: | primary E12.5 fetal-liver erythroid cells |
| Cell Type: | erythroblast |
| Cell Ontology ID: | CL:0000765 |
| Experiment Type: | Super-enhancer constituent functional assay; TF binding assay; Endogenous cis-element deletion assay; In vivo functional validation |
| High Throughput Method: | DNase-seq; GATA1/TAL1/KLF1/MED1 ChIP-seq; ATAC-seq; nascent RNA-seq; NG Capture-C |
| Low Throughput Method: | Targeted R4 deletion mouse model; NanoString; chick embryo reporter assay; stable transgenic LacZ reporter assay; hematologic phenotyping; In vivo phenotyping |
About Target Gene
| Target gene : | Hba-a2 |
About TF
| TF name : | Tal1 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|
Enhancer Associated Network
Overlapping Enhancers (mm9)
18 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_02494 | chr11:32145540-32169344 | NA | primitive erythroid lineage cell | NA |
| E_02495 | chr11:32145540-32169344 | NA | primitive erythroid lineage cell | NA |
| E_00120 | chr11:32168783-32169689 | liver | erythroblast | NA |
| E_00121 | chr11:32168783-32169689 | liver | erythroblast | NA |
| E_00122 | chr11:32168783-32169689 | liver | erythroblast | NA |
| E_00123 | chr11:32168783-32169689 | liver | erythroblast | NA |
| E_00124 | chr11:32168783-32169689 | liver | erythroblast | NA |
| E_00125 | chr11:32168783-32169689 | liver | erythroblast | NA |
| E_00126 | chr11:32168783-32169689 | liver | erythroblast | NA |
| E_00127 | chr11:32168783-32169689 | liver | erythroblast | NA |
| E_00128 | chr11:32168783-32169689 | liver | erythroblast | NA |
| E_00129 | chr11:32168783-32169689 | liver | erythroblast | NA |
| E_00130 | chr11:32168783-32169689 | liver | erythroblast | NA |
| E_03323 | chr11:32168783-32169689 | liver | erythroid cell | NA |
| E_03496 | chr11:32168783-32169689 | spleen | erythroblast | NA |
| E_03497 | chr11:32168783-32169689 | spleen | erythroblast | NA |
| E_03498 | chr11:32168783-32169689 | spleen | erythroblast | NA |
| E_03499 | chr11:32168783-32169689 | spleen | erythroblast | NA |
Expression of Target Genes for the Enhancer