About Enhancer
| Enhancer ID: | E_00136 |
| Species: | Homo sapiens |
| Position : | chr3:70961242-70974816   |
| Year: | 2026 |
| Title: | Super-enhancer-driven core transcription factor FOXP1 delays endothelial cell senescence via phase separation-mediated SESN3 activation |
| Genome Build: | hg19 |
| Enhancer Type: | Super-enhancer |
| Condition: | Disease |
| Disease Name: | Atherosclerosis |
| PMID: | 41355963 |
| MONDO: | MONDO:0005147 |
| Tissue: | Embryonic kidney |
| Tissue Ontology ID: | UBERON:0002113 |
| Cell Source: | HEK293T |
| CVCL ID: | CVCL_0063 |
| Cell Type: | human embryonic kidney cell |
| Cell Ontology ID: | CL:0002139 |
| Experiment Type: | dCas9-KRAB CRISPRi loss-of-function, dual-luciferase reporter assay, CUT&Tag-qPCR |
| High Throughput Method: | CUT&Tag(H3K27ac/H3K4me1/H3K4me3), ATAC-seq, RNA-seq |
| Low Throughput Method: | dual-luciferase reporter detection, CRISPRi lentiviral transduction, RT-qPCR, Western blot, immunofluorescence staining, DNA-FISH |
About Target Gene
| Target gene : | SESN3 |
About TF
| TF name : | FOXP1 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|
Enhancer Associated Network
Overlapping Enhancers (hg19)
13 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_00078 | chr3:70961242-70974816 | Umbilical vein | human umbilical vein endothelial cell | -- |
| E_00079 | chr3:70961242-70974816 | Embryonic kidney | human embryonic kidney cell | -- |
| E_00080 | chr3:70961242-70974816 | Umbilical vein | human umbilical vein endothelial cell | Vascular aging |
| E_00081 | chr3:70961242-70974816 | Embryonic kidney | human embryonic kidney cell | Vascular aging |
| E_00082 | chr3:70961242-70974816 | Umbilical vein | human umbilical vein endothelial cell | Atherosclerosis |
| E_00083 | chr3:70961242-70974816 | Embryonic kidney | human embryonic kidney cell | Atherosclerosis |
| E_00129 | chr3:70961242-70974816 | Umbilical vein | human umbilical vein endothelial cell | Vascular aging |
| E_00130 | chr3:70961242-70974816 | Embryonic kidney | human embryonic kidney cell | Vascular aging |
| E_00131 | chr3:70961242-70974816 | Umbilical vein | human umbilical vein endothelial cell | -- |
| E_00132 | chr3:70961242-70974816 | Embryonic kidney | human embryonic kidney cell | -- |
| E_00133 | chr3:70961242-70974816 | Umbilical vein | human umbilical vein endothelial cell | Vascular aging |
| E_00134 | chr3:70961242-70974816 | Embryonic kidney | human embryonic kidney cell | Vascular aging |
| E_00135 | chr3:70961242-70974816 | Umbilical vein | human umbilical vein endothelial cell | Atherosclerosis |
Expression of Target Genes for the Enhancer