About Enhancer
| Enhancer ID: | E_00146 |
| Species: | Homo sapiens |
| Position : | chr12:25538405-25539356   |
| Year: | 2020 |
| Title: | Noncoding Variants Connect Enhancer Dysregulation with Nuclear Receptor Signaling in Hematopoietic Malignancies |
| Genome Build: | hg19 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | acute myeloid leukemia |
| PMID: | 32188707 |
| MONDO: | MONDO:0018874 |
| Tissue: | Bone Marrow |
| Tissue Ontology ID: | UBERON:0002371 |
| Cell Source: | Primary AML cells |
| CVCL ID: | |
| Cell Type: | primary acute myeloid leukemia cell |
| Cell Ontology ID: | CL:0001054 |
| Experiment Type: | Enhancer activity assay, TF binding assay, Chromatin interaction assay, Functional perturbation assay |
| High Throughput Method: | ChIP-seq, Hi-C, RNA-seq, ATAC-seq |
| Low Throughput Method: | Luciferase Reporter Assay, CRISPR Knockout, CRISPRi, CRISPRa, ChIP-RT-qPCR, RT-RT-qPCR, Western blot |
About Target Gene
| Target gene : | KRAS |
About TF
| TF name : | PPARG |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| PPARG | Calcineurin-regulated NFAT-dependent transcription in lymphocytes | pid | 50 |
| PPARG | Noncanonical Wnt signaling pathway | pid | 33 |
| PPARG | Nuclear Receptor transcription pathway | reactome | 51 |
| PPARG | PPARA activates gene expression | reactome | 113 |
| PPARG | Regulation of retinoblastoma protein | pid | 67 |
| PPARG | RXR and RAR heterodimerization with other nuclear receptor | pid | 26 |
| PPARG | Signaling events mediated by HDAC Class I | pid | 89 |
| PPARG | Transcriptional regulation of white adipocyte differentiation | reactome | 79 |
| PPARG | Wnt | netpath | 118 |
| PPARG | PPAR signaling pathway | kegg | 67 |
| PPARG | Huntington's disease | kegg | 182 |
| PPARG | Pathways in cancer | kegg | 321 |
| PPARG | Thyroid cancer | kegg | 25 |
| PPARG | Hs_White_fat_cell_differentiation_WP3946_90940 | wikipathways | 30 |
| PPARG | Hs_p38_MAPK_Signaling_Pathway_WP400_72084 | wikipathways | 28 |
| PPARG | Hs_Nucleotide_Metabolism_WP404_68960 | wikipathways | 16 |
| PPARG | Hs_Transcription_factor_regulation_in_adipogenesis_WP3599_88581 | wikipathways | 9 |
Enhancer Associated Network
Expression of Target Genes for the Enhancer