About Enhancer
| Enhancer ID: | E_00153 |
| Species: | Homo sapiens |
| Position : | chr10:105668100-105669000   |
| Year: | 2022 |
| Title: | Functional annotation and investigation of the 10q2433 melanoma risk locus identifies a common variant that influences transcriptional regulation of OBFC1 |
| Genome Build: | hg19 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | skin melanoma |
| PMID: | 34605909 |
| MONDO: | MONDO:0005105 |
| Tissue: | Skin |
| Tissue Ontology ID: | UBERON:0000014 |
| Cell Source: | A375 |
| CVCL ID: | CVCL_0132 |
| Cell Type: | melanoma cell |
| Cell Ontology ID: | CL:0002573 |
| Experiment Type: | Enhancer activity assay, Chromatin interaction assay, Functional perturbation assay, TF binding assay |
| High Throughput Method: | ChIP-seq, RNA-seq |
| Low Throughput Method: | Luciferase Reporter Assay, 3C, CRISPR Knockout, RT-RT-qPCR, Western blot, ChIP-RT-qPCR |
About Target Gene
| Target gene : | OBFC1 |
About TF
| TF name : | MEOX2 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|
Enhancer Associated Network
Overlapping Enhancers (hg19)
4 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_00154 | chr10:105668100-105669000 | Skin | melanoma cell | skin melanoma |
| E_00155 | chr10:105668100-105669000 | Skin | melanoma cell | skin melanoma |
| E_00156 | chr10:105668100-105669000 | Neural Crest | neural crest cell | -- |
| E_00157 | chr10:105668100-105669000 | Esophagus | esophageal squamous cell carcinoma cell | esophageal squamous cell carcinoma |
Expression of Target Genes for the Enhancer