About Enhancer
| Enhancer ID: | E_00166 |
| Species: | Homo sapiens |
| Position : | chr7:128573036-128573717   |
| Year: | 2023 |
| Title: | An autoimmune pleiotropic SNP modulates IRF5 alternative promoter usage through ZBTB3-mediated chromatin looping |
| Genome Build: | hg19 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | prostate cancer |
| PMID: | 36869052 |
| MONDO: | MONDO:0008315 |
| Tissue: | Prostate |
| Tissue Ontology ID: | UBERON:0002367 |
| Cell Source: | Human prostate carcinoma cell |
| CVCL ID: | |
| Cell Type: | prostate carcinoma cell |
| Cell Ontology ID: | CL:0000066 |
| Experiment Type: | Enhancer activity assay, Chromatin interaction assay, Functional perturbation assay, TF binding assay |
| High Throughput Method: | ChIP-seq, RNA-seq, 3C-seq, ATAC-seq |
| Low Throughput Method: | Luciferase Reporter Assay, 3C assay, 4C assay, CRISPR Knockout, CRISPRi, CRISPRa, RT-RT-qPCR, Western blot, EMSA, ChIP-RT-qPCR |
About Target Gene
| Target gene : | IRF5 |
About TF
| TF name : | ZBTB3 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|
Enhancer Associated Network
Expression of Target Genes for the Enhancer