About Enhancer
| Enhancer ID: | E_00167 |
| Species: | Homo sapiens |
| Position : | chr8:128750000-129000000   |
| Year: | 2021 |
| Title: | Androgen receptor and MYC equilibration centralizes on developmental super-enhancer |
| Genome Build: | hg19 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | breast carcinoma |
| PMID: | 34911936 |
| MONDO: | MONDO:0006120 |
| Tissue: | Breast |
| Tissue Ontology ID: | UBERON:0000310 |
| Cell Source: | MCF7 |
| CVCL ID: | CVCL_0031 |
| Cell Type: | breast carcinoma cell |
| Cell Ontology ID: | CL:0000066 |
| Experiment Type: | Enhancer activity assay, TF binding assay, Chromatin interaction assay, Functional perturbation assay |
| High Throughput Method: | ChIP-seq, RNA-seq, HiChIP, 4C-seq, ATAC-seq |
| Low Throughput Method: | CRISPR knockout, RT-RT-qPCR, 3C-ddPCR, Western blot |
About Target Gene
| Target gene : | MYC |
About TF
| TF name : | AR |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| AR | Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 | reactome | 65 |
| AR | Alpha6Beta4Integrin | netpath | 74 |
| AR | AndrogenReceptor | netpath | 167 |
| AR | Coregulation of Androgen receptor activity | pid | 61 |
| AR | FOXA1 transcription factor network | pid | 45 |
| AR | IL6 | netpath | 85 |
| AR | Nongenotropic Androgen signaling | pid | 31 |
| AR | Notch-mediated HES/HEY network | pid | 48 |
| AR | Nuclear Receptor transcription pathway | reactome | 51 |
| AR | Regulation of Androgen receptor activity | pid | 54 |
| AR | Regulation of nuclear beta catenin signaling and target gene transcription | pid | 80 |
| AR | Regulation of nuclear SMAD2/3 signaling | pid | 82 |
| AR | TGF_beta_Receptor | netpath | 220 |
| AR | Oocyte meiosis | kegg | 110 |
| AR | Pathways in cancer | kegg | 321 |
| AR | Prostate cancer | kegg | 85 |
| AR | Hs_DNA_Damage_Response_WP707_82937 | wikipathways | 28 |
| AR | Hs_miRNA_Regulation_of_DNA_Damage_Response_WP1530_84694 | wikipathways | 28 |
| AR | Hs_Integrated_Breast_Cancer_Pathway_WP1984_82941 | wikipathways | 122 |
| AR | Hs_Sudden_Infant_Death_Syndrome_(SIDS)_Susceptibility_Pathways_WP706_86078 | wikipathways | 33 |
| AR | Hs_Androgen_receptor_signaling_pathway_WP138_79958 | wikipathways | 27 |
Enhancer Associated Network
Overlapping Enhancers (hg19)
28 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_00419 | chr8:128740000-128790000 | Colon | colorectal carcinoma cell | colorectal carcinoma |
| E_00112 | chr8:128745000-128752600 | Epithelium | breast epithelial cell | Cancer |
| E_00175 | chr8:128747000-128750000 | Cervical Epithelium | cervical adenocarcinoma cell | cervical cancer |
| E_00646 | chr8:128747000-128753000 | Blood | T lymphoblast | T-cell acute lymphoblastic leukemia |
| E_00945 | chr8:128747680-128753680 | Bone marrow | acute myeloid leukemia cell | acute myeloid leukemia |
| E_01102 | chr8:128748315-128750245 | Dermis | dermal lymphatic endothelial cell | -- |
| E_00595 | chr8:128748351-128800823 | Pulmonary artery | pulmonary artery endothelial cell | -- |
| E_00596 | chr8:128748351-128800823 | Prostate | prostate carcinoma cell | prostate cancer |
| E_00636 | chr8:128749000-128750000 | Esophagus | esophageal squamous cell carcinoma cell | esophageal squamous cell carcinoma |
| E_00651 | chr8:128750000-128750100 | Colon | colorectal carcinoma cell | colorectal cancer |
| E_00606 | chr8:128751884-128753219 | Colon | colon epithelial cell | -- |
| E_01293 | chr8:128753000-128754000 | Endometrium | endometrial adenocarcinoma cell | endometrial adenocarcinoma |
| E_01104 | chr8:128754000-128755000 | Breast | breast carcinoma cell | breast carcinoma |
| E_01105 | chr8:128754000-128755000 | Colon | colorectal carcinoma cell | colorectal carcinoma |
| E_00881 | chr8:128765000-128767000 | Bone Marrow | chronic myeloid leukemia cell | chronic myeloid leukemia |
| E_00882 | chr8:128765000-128767000 | Colon | colorectal carcinoma cell | colorectal carcinoma |
| E_00648 | chr8:128817000-128818000 | Breast | breast carcinoma cell | breast carcinoma |
| E_00301 | chr8:128821500-128822500 | Breast | breast carcinoma cell | breast carcinoma |
| E_00302 | chr8:128821500-128822500 | Breast | breast carcinoma cell | breast carcinoma |
| E_00454 | chr8:128835000-128837000 | Colon | colorectal carcinoma cell | colorectal carcinoma |
| E_00303 | chr8:128866000-128867000 | Breast | breast carcinoma cell | breast carcinoma |
| E_00304 | chr8:128866000-128867000 | Breast | breast carcinoma cell | breast carcinoma |
| E_00203 | chr8:128889122-128889450 | Colon | colorectal carcinoma cell | colorectal cancer |
| E_00656 | chr8:128910869-128911521 | Blood | chronic myeloid leukemia cell | chronic myeloid leukemia |
| E_00305 | chr8:128912000-128913000 | Breast | breast carcinoma cell | breast carcinoma |
| E_00306 | chr8:128912000-128913000 | Breast | breast carcinoma cell | breast carcinoma |
| E_00307 | chr8:128919000-128920000 | Colon | colorectal carcinoma cell | colorectal cancer |
| E_00657 | chr8:128972341-128973219 | Blood | chronic myeloid leukemia cell | chronic myeloid leukemia |
Expression of Target Genes for the Enhancer