About Enhancer
| Enhancer ID: | E_00175 |
| Species: | Homo sapiens |
| Position : | chr8:128747000-128750000   |
| Year: | 2021 |
| Title: | The leukemic oncogene EVI1 hijacks a MYC super-enhancer by CTCF-facilitated loops |
| Genome Build: | hg19 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | cervical cancer |
| PMID: | 34584081 |
| MONDO: | MONDO:0001156 |
| Tissue: | Cervical Epithelium |
| Tissue Ontology ID: | UBERON:0000002 |
| Cell Source: | HeLa |
| CVCL ID: | CVCL_0030 |
| Cell Type: | cervical adenocarcinoma cell |
| Cell Ontology ID: | CL:0000069 |
| Experiment Type: | Functional perturbation assay, Chromatin interaction assay, TF binding assay |
| High Throughput Method: | ChIP-seq, 4C-seq, RNA-seq |
| Low Throughput Method: | CRISPR KO, RT-RT-qPCR, Western blot |
About Target Gene
| Target gene : | MYC |
About TF
| TF name : |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|
Enhancer Associated Network
Overlapping Enhancers (hg19)
12 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_00419 | chr8:128740000-128790000 | Colon | colorectal carcinoma cell | colorectal carcinoma |
| E_00112 | chr8:128745000-128752600 | Epithelium | breast epithelial cell | Cancer |
| E_00646 | chr8:128747000-128753000 | Blood | T lymphoblast | T-cell acute lymphoblastic leukemia |
| E_01094 | chr8:128747000-128748000 | Embryonic Kidney | embryonic kidney cell | -- |
| E_00945 | chr8:128747680-128753680 | Bone marrow | acute myeloid leukemia cell | acute myeloid leukemia |
| E_00891 | chr8:128748243-128748308 | Brain | neural stem cell | -- |
| E_01102 | chr8:128748315-128750245 | Dermis | dermal lymphatic endothelial cell | -- |
| E_00595 | chr8:128748351-128800823 | Pulmonary artery | pulmonary artery endothelial cell | -- |
| E_00596 | chr8:128748351-128800823 | Prostate | prostate carcinoma cell | prostate cancer |
| E_00636 | chr8:128749000-128750000 | Esophagus | esophageal squamous cell carcinoma cell | esophageal squamous cell carcinoma |
| E_00167 | chr8:128750000-129000000 | Breast | breast carcinoma cell | breast carcinoma |
| E_00651 | chr8:128750000-128750100 | Colon | colorectal carcinoma cell | colorectal cancer |
Expression of Target Genes for the Enhancer