About Enhancer
| Enhancer ID: | E_00176 |
| Species: | Homo sapiens |
| Position : | chr1:16479332-16499332   |
| Year: | 2021 |
| Title: | EphA2 super-enhancer promotes tumor progression by recruiting FOSL2 and TCF7L2 to activate the target gene EphA2 |
| Genome Build: | hg19 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | colorectal cancer |
| PMID: | 33712565 |
| MONDO: | MONDO:0005176 |
| Tissue: | Colon |
| Tissue Ontology ID: | UBERON:0001155 |
| Cell Source: | HCT116 |
| CVCL ID: | CVCL_0291 |
| Cell Type: | colorectal carcinoma cell |
| Cell Ontology ID: | CL:0000066 |
| Experiment Type: | Enhancer activity assay, Functional perturbation assay |
| High Throughput Method: | ChIP-seq, ATAC-seq |
| Low Throughput Method: | Luciferase Reporter Assay, CRISPR Knockout, RT-RT-qPCR, Western blot |
About Target Gene
| Target gene : | EPHA2 |
About TF
| TF name : |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|
Enhancer Associated Network
Overlapping Enhancers (hg19)
5 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_00177 | chr1:16479332-16499332 | Breast | breast carcinoma cell | breast carcinoma |
| E_00178 | chr1:16479332-16499332 | Cervical Epithelium | cervical adenocarcinoma cell | cervical cancer |
| E_03479 | chr1:16479332-16539780 | Cervical Epithelium | cervical adenocarcinoma cell | cervical cancer |
| E_03480 | chr1:16479332-16539780 | Colon Epithelium | colorectal carcinoma cell | colorectal carcinoma |
| E_03481 | chr1:16479332-16539780 | Breast Epithelium | breast carcinoma cell | breast carcinoma |
Expression of Target Genes for the Enhancer