About Enhancer
| Enhancer ID: | E_00185 |
| Species: | Homo sapiens |
| Position : | chr1:42614062-42616745   |
| Year: | 2022 |
| Title: | A beta-Catenin-TCF-Sensitive Locus Control Region Mediates GUCY2C Ligand Loss in Colorectal Cancer |
| Genome Build: | hg19 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | acute myeloid leukemia |
| PMID: | 34954189 |
| MONDO: | MONDO:0018874 |
| Tissue: | Bone Marrow |
| Tissue Ontology ID: | UBERON:0002371 |
| Cell Source: | Primary AML blasts |
| CVCL ID: | |
| Cell Type: | myeloid leukemia cell |
| Cell Ontology ID: | CL:0001054 |
| Experiment Type: | Enhancer activity assay, Functional perturbation assay |
| High Throughput Method: | ChIP-seq, RNA-seq |
| Low Throughput Method: | Luciferase Reporter Assay, CRISPR Knockout, CRISPRi, CRISPRa, ChIP-RT-qPCR, RT-RT-qPCR |
About Target Gene
| Target gene : | GUCA2B |
About TF
| TF name : |
About Regulatory State
| Regulatory State : | Silenced |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|
Enhancer Associated Network
Overlapping Enhancers (hg19)
1 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_00184 | chr1:42614062-42616745 | Colon | colorectal carcinoma cell | colorectal cancer |
Expression of Target Genes for the Enhancer