About Enhancer
| Enhancer ID: | E_00189 |
| Species: | Homo sapiens |
| Position : | chr3:168866500-168868000   |
| Year: | 2021 |
| Title: | The leukemic oncogene EVI1 hijacks a MYC super-enhancer by CTCF-facilitated loops |
| Genome Build: | hg19 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | acute myeloid leukemia |
| PMID: | 34584081 |
| MONDO: | MONDO:0018874 |
| Tissue: | Bone Marrow |
| Tissue Ontology ID: | UBERON:0002371 |
| Cell Source: | Primary AML blasts |
| CVCL ID: | |
| Cell Type: | myeloid leukemia cell |
| Cell Ontology ID: | CL:0001054 |
| Experiment Type: | Chromatin interaction assay, Functional perturbation assay, TF binding assay |
| High Throughput Method: | ChIP-seq, 4C-seq, RNA-seq |
| Low Throughput Method: | CRISPR Knockout, RT-RT-qPCR, Western blot, Flow Cytometry, FISH |
About Target Gene
| Target gene : | EVI1 |
About TF
| TF name : | CTCF |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| CTCF | Activation of anterior HOX genes in hindbrain development during early embryogenesis | reactome | 120 |
| CTCF | TGF_beta_Receptor | netpath | 220 |
Enhancer Associated Network
Overlapping Enhancers (hg19)
4 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_00187 | chr3:168855000-168870000 | Peripheral Blood | chronic myeloid leukemia cell | chronic myeloid leukemia |
| E_00188 | chr3:168855000-168870000 | Bone Marrow | myeloid leukemia cell | acute myeloid leukemia |
| E_00190 | chr3:168866500-168868000 | Peripheral Blood | chronic myeloid leukemia cell | chronic myeloid leukemia |
| E_00191 | chr3:168866500-168868000 | Bone Marrow | myeloid leukemia cell | acute myeloid leukemia |
Expression of Target Genes for the Enhancer