About Enhancer
| Enhancer ID: | E_00195 |
| Species: | Homo sapiens |
| Position : | chr8:130475000-130775000   |
| Year: | 2021 |
| Title: | The leukemic oncogene EVI1 hijacks a MYC super-enhancer by CTCF-facilitated loops |
| Genome Build: | hg19 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | prostate cancer |
| PMID: | 34584081 |
| MONDO: | MONDO:0008315 |
| Tissue: | Prostate |
| Tissue Ontology ID: | UBERON:0002367 |
| Cell Source: | 22Rv1 |
| CVCL ID: | CVCL_1045 |
| Cell Type: | prostate carcinoma cell |
| Cell Ontology ID: | CL:0000066 |
| Experiment Type: | Enhancer activity assay, Chromatin interaction assay, Functional perturbation assay |
| High Throughput Method: | ChIP-seq, RNA-seq, 3C-seq, 4C-seq |
| Low Throughput Method: | CRISPR Knockout, RT-RT-qPCR, Western blot, FISH |
About Target Gene
| Target gene : | EVI1 |
About TF
| TF name : |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|
Enhancer Associated Network
Overlapping Enhancers (hg19)
9 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_00194 | chr8:130475000-130775000 | Peripheral Blood | acute monocytic leukemia cell | acute monocytic leukemia |
| E_00226 | chr8:130548000-130549050 | Bone Marrow | myeloid leukemia cell | acute myeloid leukemia |
| E_00227 | chr8:130548000-130549050 | Peripheral Blood | chronic myeloid leukemia cell | chronic myeloid leukemia |
| E_03482 | chr8:130550000-130551100 | Bone Marrow | myeloid leukemia cell | acute myeloid leukemia |
| E_03483 | chr8:130550000-130551100 | Peripheral Blood | K562 erythroleukemia cell | acute myeloid leukemia |
| E_03484 | chr8:130550000-130551100 | Bone Marrow | CD34-positive hematopoietic stem cell | acute myeloid leukemia |
| E_03485 | chr8:130580000-130581100 | Peripheral Blood | K562 erythroleukemia cell | acute myeloid leukemia |
| E_03486 | chr8:130580000-130581100 | Bone Marrow | myeloid leukemia cell | acute myeloid leukemia |
| E_03487 | chr8:130580000-130581100 | Bone Marrow | CD34-positive hematopoietic stem cell | acute myeloid leukemia |
Expression of Target Genes for the Enhancer