About Enhancer
| Enhancer ID: | E_00203 |
| Species: | Homo sapiens |
| Position : | chr8:128889122-128889450   |
| Year: | 2016 |
| Title: | Genetic variation at the 8q2421 renal cancer susceptibility locus affects HIF binding to a MYC enhancer |
| Genome Build: | hg19 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | colorectal cancer |
| PMID: | 27774982 |
| MONDO: | MONDO:0005176 |
| Tissue: | Colon |
| Tissue Ontology ID: | UBERON:0001155 |
| Cell Source: | Colorectal carcinoma cells |
| CVCL ID: | |
| Cell Type: | colorectal carcinoma cell |
| Cell Ontology ID: | CL:0000066 |
| Experiment Type: | Enhancer activity assay, Functional perturbation assay, Chromatin interaction assay |
| High Throughput Method: | ChIP-seq, Hi-C |
| Low Throughput Method: | Luciferase Reporter Assay, CRISPR Knockout |
About Target Gene
| Target gene : | MYC |
About TF
| TF name : | HIF1A |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| HIF1A | Angiogenesis | panther | 141 |
| HIF1A | AP-1 transcription factor network | pid | 71 |
| HIF1A | BMAL1:CLOCK,NPAS2 activates circadian gene expression | reactome | 42 |
| HIF1A | Circadian Clock | reactome | 49 |
| HIF1A | HIF-1-alpha transcription factor network | pid | 67 |
| HIF1A | Hypoxia response via HIF activation | panther | 16 |
| HIF1A | Hypoxic and oxygen homeostasis regulation of HIF-1-alpha | pid | 19 |
| HIF1A | Notch-mediated HES/HEY network | pid | 48 |
| HIF1A | NOTCH1 Intracellular Domain Regulates Transcription | reactome | 47 |
| HIF1A | Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha | reactome | 18 |
| HIF1A | Parkinson disease | panther | 85 |
| HIF1A | PTK6 Expression | reactome | 5 |
| HIF1A | PTK6 promotes HIF1A stabilization | reactome | 6 |
| HIF1A | Regulation of gene expression by Hypoxia-inducible Factor | reactome | 10 |
| HIF1A | VEGF signaling pathway | panther | 54 |
| HIF1A | VEGFR1 specific signals | pid | 29 |
| HIF1A | mTOR signaling pathway | kegg | 50 |
| HIF1A | Pathways in cancer | kegg | 321 |
| HIF1A | Renal cell carcinoma | kegg | 65 |
| HIF1A | Hs_Hepatitis_C_and_Hepatocellular_Carcinoma_WP3646_88640 | wikipathways | 36 |
| HIF1A | Hs_Focal_Adhesion-PI3K-Akt-mTOR-signaling_pathway_WP3932_91101 | wikipathways | 8 |
| HIF1A | Hs_AGE-RAGE_pathway_WP2324_89798 | wikipathways | 27 |
| HIF1A | Hs_Notch_Signaling_Pathway_WP61_78592 | wikipathways | 16 |
Enhancer Associated Network
Overlapping Enhancers (hg19)
1 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_00167 | chr8:128750000-129000000 | Breast | breast carcinoma cell | breast carcinoma |
Expression of Target Genes for the Enhancer