About Enhancer
| Enhancer ID: | E_00210 |
| Species: | Homo sapiens |
| Position : | chr14:101283029-101284356   |
| Year: | 2024 |
| Title: | DLK1/DIO3 locus upregulation by a ??-catenin-dependent enhancer drives cell proliferation and liver tumorigenesis |
| Genome Build: | hg19 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | acute monocytic leukemia |
| PMID: | 38311851 |
| MONDO: | MONDO:0005025 |
| Tissue: | Peripheral Blood |
| Tissue Ontology ID: | UBERON:0000178 |
| Cell Source: | THP-6 |
| CVCL ID: | CVCL_4686 |
| Cell Type: | acute monocytic leukemia cell |
| Cell Ontology ID: | CL:0000576 |
| Experiment Type: | Functional perturbation assay, Chromatin interaction assay, TF binding assay |
| High Throughput Method: | ChIP-seq, ATAC-seq, RNA-seq |
| Low Throughput Method: | CRISPR Knockout, CRISPRi, 3C-RT-qPCR, ChIP-RT-qPCR |
About Target Gene
| Target gene : | MEG3 |
About TF
| TF name : | TCF4 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| TCF4 | AndrogenReceptor | netpath | 167 |
| TCF4 | CDO in myogenesis | reactome | 29 |
| TCF4 | Coregulation of Androgen receptor activity | pid | 61 |
| TCF4 | Formation of the beta-catenin:TCF transactivating complex | reactome | 88 |
| TCF4 | ID | netpath | 38 |
| TCF4 | Regulation of nuclear beta catenin signaling and target gene transcription | pid | 80 |
| TCF4 | TGF_beta_Receptor | netpath | 220 |
| TCF4 | Wnt | netpath | 118 |
| TCF4 | Hs_Corticotropin-releasing_hormone_signaling_pathway_WP2355_90017 | wikipathways | 41 |
Enhancer Associated Network
Overlapping Enhancers (hg19)
1 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_00211 | chr14:101283029-101284356 | Prostate | prostate carcinoma cell | prostate cancer |
Expression of Target Genes for the Enhancer