About Enhancer
| Enhancer ID: | E_00214 |
| Species: | Homo sapiens |
| Position : | chr8:128531465-128532665   |
| Year: | 2021 |
| Title: | CRISPRi screens reveal a DNA methylation mediated 3D genome dependent causal mechanism in prostate cancer |
| Genome Build: | hg19 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | glioblastoma |
| PMID: | 33741908 |
| MONDO: | MONDO:0005142 |
| Tissue: | Brain |
| Tissue Ontology ID: | UBERON:0000955 |
| Cell Source: | GBM3565 glioblastoma |
| CVCL ID: | |
| Cell Type: | glioblastoma cell |
| Cell Ontology ID: | CL:0000127 |
| Experiment Type: | Functional perturbation assay, Chromatin interaction assay, TF binding assay |
| High Throughput Method: | CRISPRi screening, ChIP-seq, RNA-seq, Hi-C, 5C |
| Low Throughput Method: | CRISPRi, RT-RT-qPCR, 3C assay, Cell proliferation assay, Mouse xenograft assay |
About Target Gene
| Target gene : | MYC |
About TF
| TF name : | AR |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| AR | Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 | reactome | 65 |
| AR | Alpha6Beta4Integrin | netpath | 74 |
| AR | AndrogenReceptor | netpath | 167 |
| AR | Coregulation of Androgen receptor activity | pid | 61 |
| AR | FOXA1 transcription factor network | pid | 45 |
| AR | IL6 | netpath | 85 |
| AR | Nongenotropic Androgen signaling | pid | 31 |
| AR | Notch-mediated HES/HEY network | pid | 48 |
| AR | Nuclear Receptor transcription pathway | reactome | 51 |
| AR | Regulation of Androgen receptor activity | pid | 54 |
| AR | Regulation of nuclear beta catenin signaling and target gene transcription | pid | 80 |
| AR | Regulation of nuclear SMAD2/3 signaling | pid | 82 |
| AR | TGF_beta_Receptor | netpath | 220 |
| AR | Oocyte meiosis | kegg | 110 |
| AR | Pathways in cancer | kegg | 321 |
| AR | Prostate cancer | kegg | 85 |
| AR | Hs_DNA_Damage_Response_WP707_82937 | wikipathways | 28 |
| AR | Hs_miRNA_Regulation_of_DNA_Damage_Response_WP1530_84694 | wikipathways | 28 |
| AR | Hs_Integrated_Breast_Cancer_Pathway_WP1984_82941 | wikipathways | 122 |
| AR | Hs_Sudden_Infant_Death_Syndrome_(SIDS)_Susceptibility_Pathways_WP706_86078 | wikipathways | 33 |
| AR | Hs_Androgen_receptor_signaling_pathway_WP138_79958 | wikipathways | 27 |
Enhancer Associated Network
Overlapping Enhancers (hg19)
9 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_00908 | chr8:128311200-128667652 | Brain | medulloblastoma cell | medulloblastoma |
| E_01135 | chr8:128520000-128551676 | Stomach | esophageal adenocarcinoma cell | esophageal adenocarcinoma |
| E_01136 | chr8:128520000-128551676 | Prostate | prostate carcinoma cell | prostate cancer |
| E_01137 | chr8:128520000-128551676 | Prostate | prostate carcinoma cell | prostate cancer |
| E_01138 | chr8:128520000-128551676 | Prostate | prostate epithelial cell | -- |
| E_00199 | chr8:128531465-128532665 | Embryonic Kidney | embryonic kidney cell | -- |
| E_00200 | chr8:128531465-128532665 | Skin | melanoma cell | skin melanoma |
| E_00201 | chr8:128531465-128532665 | Skin | melanoma cell | skin melanoma |
| E_00202 | chr8:128531465-128532665 | Umbilical vein | umbilical vein endothelial cell | -- |
Expression of Target Genes for the Enhancer