About Enhancer
| Enhancer ID: | E_00222 |
| Species: | Homo sapiens |
| Position : | chr20:53730511-53757381   |
| Year: | 2022 |
| Title: | A multi-omic dissection of super-enhancer driven oncogenic gene expression programs in ovarian cancer |
| Genome Build: | hg19 |
| Enhancer Type: | Super-enhancer |
| Condition: | Disease |
| Disease Name: | ovarian carcinoma |
| PMID: | 35869079 |
| MONDO: | MONDO:0005140 |
| Tissue: | Ovary |
| Tissue Ontology ID: | UBERON:0000992 |
| Cell Source: | OVCAR3 |
| CVCL ID: | CVCL_0465 |
| Cell Type: | ovarian carcinoma cell |
| Cell Ontology ID: | CL:0000069 |
| Experiment Type: | Enhancer activity assay, TF binding assay, Chromatin interaction assay, Functional perturbation assay |
| High Throughput Method: | ChIP-seq, RNA-seq, Hi-C, ATAC-seq, scATAC-seq, scRNA-seq |
| Low Throughput Method: | CRISPR Knockout, CRISPRi, qRT-PCR, Western blot, Cell Proliferation Assay, Cell Migration Assay |
About Target Gene
| Target gene : | RAE1 |
About TF
| TF name : | SOX4 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| SOX4 | Deactivation of the beta-catenin transactivating complex | reactome | 42 |
| SOX4 | IL5 | netpath | 59 |
Enhancer Associated Network
Overlapping Enhancers (hg19)
No overlapping enhancers found in hg19 at this locus.
Expression of Target Genes for the Enhancer