About Enhancer
| Enhancer ID: | E_00238 |
| Species: | Homo sapiens |
| Position : | chr3:181465000-181468600   |
| Year: | 2017 |
| Title: | NFATc2 enhances tumor-initiating phenotypes through the NFATc2/SOX2/ALDH axis in lung adenocarcinoma |
| Genome Build: | hg19 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | non-small cell lung carcinoma |
| PMID: | 28737489 |
| MONDO: | MONDO:0005233 |
| Tissue: | Lung |
| Tissue Ontology ID: | UBERON:0002048 |
| Cell Source: | H1299 |
| CVCL ID: | CVCL_0060 |
| Cell Type: | non-small cell lung carcinoma cell |
| Cell Ontology ID: | CL:0000066 |
| Experiment Type: | Functional perturbation assay |
| High Throughput Method: | ChIP-seq, RNA-seq |
| Low Throughput Method: | CRISPR Knockout, Luciferase Reporter Assay |
About Target Gene
| Target gene : | SOX2 |
About TF
| TF name : | NFATC2 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| NFATC2 | AP-1 transcription factor network | pid | 71 |
| NFATC2 | Axon guidance mediated by netrin | panther | 30 |
| NFATC2 | BCR | netpath | 161 |
| NFATC2 | Calcineurin-regulated NFAT-dependent transcription in lymphocytes | pid | 50 |
| NFATC2 | Calcium signaling in the CD4+ TCR pathway | pid | 29 |
| NFATC2 | CLEC7A (Dectin-1) induces NFAT activation | reactome | 13 |
| NFATC2 | Downstream signaling in naïve CD8+ T cells | pid | 69 |
| NFATC2 | Fc-epsilon receptor I signaling in mast cells | pid | 64 |
| NFATC2 | FCERI mediated Ca+2 mobilization | reactome | 41 |
| NFATC2 | Glucocorticoid receptor regulatory network | pid | 85 |
| NFATC2 | IL12 signaling mediated by STAT4 | pid | 33 |
| NFATC2 | IL2 signaling events mediated by PI3K | pid | 38 |
| NFATC2 | Inflammation mediated by chemokine and cytokine signaling pathway | panther | 189 |
| NFATC2 | KitReceptor | netpath | 104 |
| NFATC2 | Noncanonical Wnt signaling pathway | pid | 33 |
| NFATC2 | Role of Calcineurin-dependent NFAT signaling in lymphocytes | pid | 54 |
| NFATC2 | Signaling by Wnt | reactome | 10 |
| NFATC2 | TCR | netpath | 261 |
| NFATC2 | Validated transcriptional targets of AP1 family members Fra1 and Fra2 | pid | 37 |
| NFATC2 | Wnt | netpath | 118 |
| NFATC2 | Wnt signaling pathway | panther | 250 |
| NFATC2 | Wnt signaling pathway | kegg | 135 |
| NFATC2 | Axon guidance | kegg | 126 |
| NFATC2 | VEGF signaling pathway | kegg | 70 |
| NFATC2 | Natural killer cell mediated cytotoxicity | kegg | 125 |
| NFATC2 | T cell receptor signaling pathway | kegg | 105 |
| NFATC2 | B cell receptor signaling pathway | kegg | 70 |
| NFATC2 | Hs_T-Cell_antigen_Receptor_(TCR)_pathway_during_Staphylococcus_aureus_infection_WP3863_90702 | wikipathways | 35 |
| NFATC2 | Hs_VEGFA-VEGFR2_Signaling_Pathway_WP3888_90000 | wikipathways | 153 |
| NFATC2 | Hs_Cardiac_Hypertrophic_Response_WP2795_85087 | wikipathways | 23 |
| NFATC2 | Hs_T-Cell_antigen_Receptor_(TCR)_Signaling_Pathway_WP69_89937 | wikipathways | 60 |
| NFATC2 | Hs_B_Cell_Receptor_Signaling_Pathway_WP23_89900 | wikipathways | 71 |
Enhancer Associated Network
Overlapping Enhancers (hg19)
1 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_00239 | chr3:181465000-181468600 | Vascular tissue | endothelial cell | -- |
Expression of Target Genes for the Enhancer