About Enhancer
| Enhancer ID: | E_00246 |
| Species: | Homo sapiens |
| Position : | chr8:128533830-128534830   |
| Year: | 2023 |
| Title: | MLL-AF4 cooperates with PAF1 and FACT to drive high-density enhancer interactions in leukemia |
| Genome Build: | hg19 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | T-cell acute lymphoblastic leukemia |
| PMID: | 37626123 |
| MONDO: | MONDO:0004947 |
| Tissue: | Bone Marrow |
| Tissue Ontology ID: | UBERON:0002371 |
| Cell Source: | Primary T-ALL cells |
| CVCL ID: | |
| Cell Type: | T lymphoblast |
| Cell Ontology ID: | CL:0002419 |
| Experiment Type: | Enhancer activity assay, Functional perturbation assay |
| High Throughput Method: | ChIP-seq, Hi-C |
| Low Throughput Method: | Luciferase Reporter Assay, CRISPRi |
About Target Gene
| Target gene : | MYC |
About TF
| TF name : |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|
Enhancer Associated Network
Overlapping Enhancers (hg19)
5 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_00908 | chr8:128311200-128667652 | Brain | medulloblastoma cell | medulloblastoma |
| E_01135 | chr8:128520000-128551676 | Stomach | esophageal adenocarcinoma cell | esophageal adenocarcinoma |
| E_01136 | chr8:128520000-128551676 | Prostate | prostate carcinoma cell | prostate cancer |
| E_01137 | chr8:128520000-128551676 | Prostate | prostate carcinoma cell | prostate cancer |
| E_01138 | chr8:128520000-128551676 | Prostate | prostate epithelial cell | -- |
Expression of Target Genes for the Enhancer