About Enhancer
| Enhancer ID: | E_00250 |
| Species: | Homo sapiens |
| Position : | chr1:47677466-47678021   |
| Year: | 2023 |
| Title: | TAL1 activation in T-cell acute lymphoblastic leukemia: a novel oncogenic 3' neo-enhancer |
| Genome Build: | hg19 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | acute myeloid leukemia |
| PMID: | 36632736 |
| MONDO: | MONDO:0018874 |
| Tissue: | Bone Marrow |
| Tissue Ontology ID: | UBERON:0002371 |
| Cell Source: | GDM-1 |
| CVCL ID: | CVCL_1230 |
| Cell Type: | myeloid leukemia cell |
| Cell Ontology ID: | CL:0001054 |
| Experiment Type: | Enhancer activity assay, TF binding assay, Functional perturbation assay |
| High Throughput Method: | ChIP-seq, RNA-seq |
| Low Throughput Method: | Luciferase Reporter Assay, CRISPR Knockout, ChIP-RT-qPCR, RT-RT-qPCR, Western blot |
About Target Gene
| Target gene : | TAL1 |
About TF
| TF name : | MYB |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| MYB | AP-1 transcription factor network | pid | 71 |
| MYB | C-MYB transcription factor network | pid | 87 |
| MYB | Factors involved in megakaryocyte development and platelet production | reactome | 111 |
| MYB | IL2 signaling events mediated by PI3K | pid | 38 |
| MYB | IL4-mediated signaling events | pid | 66 |
| MYB | Notch-mediated HES/HEY network | pid | 48 |
| MYB | Prolactin | netpath | 105 |
| MYB | Hs_Neural_Crest_Differentiation_WP2064_79263 | wikipathways | 40 |
Enhancer Associated Network
Overlapping Enhancers (hg19)
3 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_00247 | chr1:47677466-47678021 | Blood | T lymphoblast | T-cell acute lymphoblastic leukemia |
| E_00248 | chr1:47677466-47678021 | Blood | T lymphoblast | T-cell acute lymphoblastic leukemia |
| E_00249 | chr1:47677466-47678021 | Blood | patient-derived xenograft cell | T-cell acute lymphoblastic leukemia |
Expression of Target Genes for the Enhancer