About Enhancer
| Enhancer ID: | E_00252 |
| Species: | Homo sapiens |
| Position : | chr14:98602411-98675204   |
| Year: | 2023 |
| Title: | Structural Variation Cooperates with Permissive Chromatin to Control Enhancer Hijacking-Mediated Oncogenic Transcription |
| Genome Build: | hg19 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | T-cell acute lymphoblastic leukemia |
| PMID: | 36947815 |
| MONDO: | MONDO:0004947 |
| Tissue: | Bone Marrow |
| Tissue Ontology ID: | UBERON:0002371 |
| Cell Source: | UT242 |
| CVCL ID: | |
| Cell Type: | T lymphoblast |
| Cell Ontology ID: | CL:0002419 |
| Experiment Type: | Enhancer activity assay, Chromatin interaction assay, Functional perturbation assay |
| High Throughput Method: | ChIP-seq, ATAC-seq, Hi-C, 4C-seq, RNA-seq |
| Low Throughput Method: | CRISPRi, RT-RT-qPCR, FISH |
About Target Gene
| Target gene : | TLX3 |
About TF
| TF name : | MYB |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| MYB | AP-1 transcription factor network | pid | 71 |
| MYB | C-MYB transcription factor network | pid | 87 |
| MYB | Factors involved in megakaryocyte development and platelet production | reactome | 111 |
| MYB | IL2 signaling events mediated by PI3K | pid | 38 |
| MYB | IL4-mediated signaling events | pid | 66 |
| MYB | Notch-mediated HES/HEY network | pid | 48 |
| MYB | Prolactin | netpath | 105 |
| MYB | Hs_Neural_Crest_Differentiation_WP2064_79263 | wikipathways | 40 |
Enhancer Associated Network
Overlapping Enhancers (hg19)
4 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_00253 | chr14:98602411-98675204 | Bone Marrow | T lymphoblast | T-cell acute lymphoblastic leukemia |
| E_00254 | chr14:98602411-98675204 | Lymph node | B cell | diffuse large B-cell lymphoma |
| E_01276 | chr14:98602411-98675204 | Blood | T lymphoblast | T-cell acute lymphoblastic leukemia |
| E_01277 | chr14:98602411-98675204 | Blood | T lymphoblast | T-cell acute lymphoblastic leukemia |
Expression of Target Genes for the Enhancer