About Enhancer
| Enhancer ID: | E_00256 |
| Species: | Homo sapiens |
| Position : | chr8:129180000-129190000   |
| Year: | 2025 |
| Title: | Selective Enhancer Dependencies in MYC-Intact and MYC-Rearranged Germinal Center B-cell Diffuse Large B-cell Lymphoma |
| Genome Build: | hg19 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | diffuse large B-cell lymphoma |
| PMID: | 40067173 |
| MONDO: | MONDO:0005042 |
| Tissue: | Lymph node |
| Tissue Ontology ID: | UBERON:0000029 |
| Cell Source: | HT |
| CVCL ID: | |
| Cell Type: | B cell |
| Cell Ontology ID: | CL:0000945 |
| Experiment Type: | Enhancer activity assay, Functional perturbation assay |
| High Throughput Method: | ChIP-seq, ATAC-seq, RNA-seq |
| Low Throughput Method: | CRISPRi, Luciferase Reporter Assay, RT-RT-qPCR |
About Target Gene
| Target gene : | MYC |
About TF
| TF name : | MEF2B; POU2F2; POU2AF1 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|
Enhancer Associated Network
Overlapping Enhancers (hg19)
8 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_00404 | chr8:129166547-129190290 | Lung | non-small cell lung carcinoma cell | non-small cell lung carcinoma |
| E_00255 | chr8:129180000-129190000 | Lymph node | B cell | diffuse large B-cell lymphoma |
| E_00257 | chr8:129180000-129190000 | Lymph node | B cell | Burkitt lymphoma |
| E_00258 | chr8:129180000-129190000 | Lymph node | B cell | diffuse large B-cell lymphoma |
| E_00259 | chr8:129190000-129195000 | Lymph node | B cell | diffuse large B-cell lymphoma |
| E_00260 | chr8:129190000-129195000 | Lymph node | B cell | diffuse large B-cell lymphoma |
| E_00261 | chr8:129190000-129195000 | Lymph node | B cell | Burkitt lymphoma |
| E_00262 | chr8:129190000-129195000 | Blood | leukemia cell | leukemia |
Expression of Target Genes for the Enhancer