About Enhancer
| Enhancer ID: | E_00264 |
| Species: | Homo sapiens |
| Position : | chr12:2880430-3018116   |
| Year: | 2022 |
| Title: | A histidine cluster determines YY1-compartmentalized coactivators and chromatin elements in phase-separated enhancer clusters |
| Genome Build: | hg19 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | breast carcinoma |
| PMID: | 35390165 |
| MONDO: | MONDO:0006120 |
| Tissue: | Breast |
| Tissue Ontology ID: | UBERON:0000310 |
| Cell Source: | MCF-7 |
| CVCL ID: | CVCL_0031 |
| Cell Type: | breast carcinoma cell |
| Cell Ontology ID: | CL:0000066 |
| Experiment Type: | Functional perturbation assay, Chromatin interaction assay, Enhancer activity assay |
| High Throughput Method: | ChIP-seq, RNA-seq |
| Low Throughput Method: | Luciferase Reporter Assay, ChIP-RT-qPCR, RT-RT-qPCR, Western blot, 3C, FISH, EMSA, FRAP |
About Target Gene
| Target gene : | FOXM1 |
About TF
| TF name : | YY1 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| YY1 | Activation of anterior HOX genes in hindbrain development during early embryogenesis | reactome | 120 |
| YY1 | DNA Damage Recognition in GG-NER | reactome | 38 |
| YY1 | E2F transcription factor network | pid | 77 |
| YY1 | mTOR signaling pathway | pid | 66 |
| YY1 | Notch-mediated HES/HEY network | pid | 48 |
| YY1 | Notch | netpath | 76 |
| YY1 | Notch signaling pathway | pid | 58 |
| YY1 | p53 pathway | pid | 59 |
| YY1 | Signaling events mediated by HDAC Class I | pid | 89 |
Enhancer Associated Network
Overlapping Enhancers (hg19)
4 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_00265 | chr12:2880430-3018116 | Bone | osteosarcoma cell | osteosarcoma |
| E_00266 | chr12:2880430-3018116 | Cervix | cervical adenocarcinoma cell | cervical cancer |
| E_00267 | chr12:2880430-3018116 | Embryonic Kidney | embryonic kidney cell | -- |
| E_00268 | chr12:2880430-3018116 | Pancreatic islet | pancreatic beta cell | -- |
Expression of Target Genes for the Enhancer