About Enhancer
| Enhancer ID: | E_00269 |
| Species: | Homo sapiens |
| Position : | chr11:1713879-1716230   |
| Year: | 2021 |
| Title: | Large parental differences in chromatin organization in pancreatic beta cell line explaining diabetes susceptibility effects |
| Genome Build: | hg19 |
| Enhancer Type: | Enhancer |
| Condition: | Normal |
| Disease Name: | -- |
| PMID: | 34267199 |
| MONDO: | |
| Tissue: | Pancreatic islet |
| Tissue Ontology ID: | UBERON:0000006 |
| Cell Source: | primary human pancreatic islets |
| CVCL ID: | |
| Cell Type: | pancreatic islet cell |
| Cell Ontology ID: | CL:0000168 |
| Experiment Type: | Enhancer activity assay, Chromatin interaction assay, Functional perturbation assay |
| High Throughput Method: | 3C-seq, 4C-seq, ChIP-seq, RNA-seq, ATAC-seq |
| Low Throughput Method: | CRISPR Knockout, RT-RT-qPCR, EMSA, Sanger Sequencing |
About Target Gene
| Target gene : | INS |
About TF
| TF name : | CTCF |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| CTCF | Activation of anterior HOX genes in hindbrain development during early embryogenesis | reactome | 120 |
| CTCF | TGF_beta_Receptor | netpath | 220 |
Enhancer Associated Network
Overlapping Enhancers (hg19)
1 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_00270 | chr11:1713879-1716230 | Cranial neural crest | cranial neural crest cell | -- |
Expression of Target Genes for the Enhancer