About Enhancer
| Enhancer ID: | E_00276 |
| Species: | Homo sapiens |
| Position : | chr2:188184262-188184791   |
| Year: | 2024 |
| Title: | Coronary Artery Disease risk variant dampens the expression of CALCRL by reducing HSF binding to shear stress responsive enhancer in endothelial cells in vitro |
| Genome Build: | hg19 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | cervical cancer |
| PMID: | 38602103 |
| MONDO: | MONDO:0001156 |
| Tissue: | Cervix |
| Tissue Ontology ID: | UBERON:0000002 |
| Cell Source: | Human cervical adenocarcinoma cell |
| CVCL ID: | |
| Cell Type: | cervical adenocarcinoma cell |
| Cell Ontology ID: | CL:0000069 |
| Experiment Type: | Enhancer activity assay, TF binding assay, Functional perturbation assay |
| High Throughput Method: | ATAC-seq, RNA-seq, ChIP-seq |
| Low Throughput Method: | Luciferase Reporter Assay, CRISPR-Cas9 Knockout, ChIP-RT-qPCR, EMSA, RT-RT-qPCR |
About Target Gene
| Target gene : | CALCRL |
About TF
| TF name : | HSF1 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| HSF1 | Attenuation phase | reactome | 28 |
| HSF1 | HSF1-dependent transactivation | reactome | 34 |
| HSF1 | HSF1 activation | reactome | 31 |
| HSF1 | p73 transcription factor network | pid | 80 |
| HSF1 | Regulation of HSF1-mediated heat shock response | reactome | 82 |
| HSF1 | Hs_DNA_IR-Double_Strand_Breaks_(DSBs)_and_cellular_response_via_ATM_WP3959_91367 | wikipathways | 50 |
Enhancer Associated Network
Overlapping Enhancers (hg19)
No overlapping enhancers found in hg19 at this locus.
Expression of Target Genes for the Enhancer