About Enhancer
| Enhancer ID: | E_00292 |
| Species: | Homo sapiens |
| Position : | chr12:85074000-85075186   |
| Year: | 2020 |
| Title: | Generation of onco-enhancer enhances chromosomal remodeling and accelerates tumorigenesis |
| Genome Build: | hg19 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | colorectal cancer |
| PMID: | 33196849 |
| MONDO: | MONDO:0005176 |
| Tissue: | Colon |
| Tissue Ontology ID: | UBERON:0001155 |
| Cell Source: | HCT116 |
| CVCL ID: | CVCL_0291 |
| Cell Type: | colorectal carcinoma cell |
| Cell Ontology ID: | CL:0000066 |
| Experiment Type: | Functional perturbation assay, Chromatin interaction assay, Enhancer activity assay |
| High Throughput Method: | ChIP-seq, RNA-seq, 3C-seq |
| Low Throughput Method: | CRISPR Knockout, ChIP-RT-qPCR, 3C assay, qRT-PCR, Western blot, Colony formation assay, Wound healing assay |
About Target Gene
| Target gene : | NTS |
About TF
| TF name : | CTCF |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| CTCF | Activation of anterior HOX genes in hindbrain development during early embryogenesis | reactome | 120 |
| CTCF | TGF_beta_Receptor | netpath | 220 |
Enhancer Associated Network
Overlapping Enhancers (hg19)
1 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_00382 | chr12:85074370-85074815 | Skin | -- | skin melanoma |
Expression of Target Genes for the Enhancer