About Enhancer
| Enhancer ID: | E_00293 |
| Species: | Homo sapiens |
| Position : | chr13:74003796-74004073   |
| Year: | 2022 |
| Title: | A stem cell marker KLF5 regulates CCAT1 via three-dimensional genome structure in colorectal cancer cells |
| Genome Build: | hg19 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | colorectal cancer |
| PMID: | 34707247 |
| MONDO: | MONDO:0005176 |
| Tissue: | Colon |
| Tissue Ontology ID: | UBERON:0001155 |
| Cell Source: | SW480 |
| CVCL ID: | CVCL_0546 |
| Cell Type: | colorectal carcinoma cell |
| Cell Ontology ID: | CL:0000066 |
| Experiment Type: | Functional perturbation assay, Chromatin interaction assay, TF binding assay |
| High Throughput Method: | enChIP-seq, ChIP-seq, RNA-seq, DNase-seq |
| Low Throughput Method: | CRISPR Knockout, CRISPRi, ChIP-RT-qPCR, RT-RT-qPCR, Sphere-formation Assay, Cell Viability Assay, Flow Cytometry |
About Target Gene
| Target gene : | KLF5 |
About TF
| TF name : | KLF5 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| KLF5 | Transcriptional regulation of white adipocyte differentiation | reactome | 79 |
| KLF5 | Hs_TGF-beta_Receptor_Signaling_WP560_90187 | wikipathways | 28 |
Enhancer Associated Network
Overlapping Enhancers (hg19)
1 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_00294 | chr13:74003796-74004073 | Colon | colorectal carcinoma cell | colorectal cancer |
Expression of Target Genes for the Enhancer