About Enhancer
| Enhancer ID: | E_00295 |
| Species: | Homo sapiens |
| Position : | chr8:128231146-128231713   |
| Year: | 2022 |
| Title: | A stem cell marker KLF5 regulates CCAT1 via three-dimensional genome structure in colorectal cancer cells |
| Genome Build: | hg19 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | breast carcinoma |
| PMID: | 34707247 |
| MONDO: | MONDO:0006120 |
| Tissue: | Breast |
| Tissue Ontology ID: | UBERON:0000310 |
| Cell Source: | MCF-7 |
| CVCL ID: | CVCL_0031 |
| Cell Type: | breast carcinoma cell |
| Cell Ontology ID: | CL:0000066 |
| Experiment Type: | Enhancer activity assay, TF binding assay, Chromatin interaction assay, Functional perturbation assay |
| High Throughput Method: | enChIP-seq, ChIP-seq, RNA-seq |
| Low Throughput Method: | CRISPR Knockout, ChIP-RT-qPCR, RT-RT-qPCR, Immunohistochemistry, RNA in situ Hybridization |
About Target Gene
| Target gene : | CCAT1 |
About TF
| TF name : | KLF5 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| KLF5 | Transcriptional regulation of white adipocyte differentiation | reactome | 79 |
| KLF5 | Hs_TGF-beta_Receptor_Signaling_WP560_90187 | wikipathways | 28 |
Enhancer Associated Network
Overlapping Enhancers (hg19)
7 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_00801 | chr8:128210000-128260000 | Breast | breast carcinoma cell | breast carcinoma |
| E_00819 | chr8:128210000-128260000 | Breast | breast carcinoma cell | breast carcinoma |
| E_01120 | chr8:128220000-128250000 | Heart | cardiomyocyte | -- |
| E_01121 | chr8:128220000-128250000 | Blood | lymphoblastoid cell | -- |
| E_00378 | chr8:128230503-128380503 | Colon | colorectal carcinoma cell | colorectal carcinoma |
| E_00379 | chr8:128230503-128380503 | Colon | colorectal carcinoma cell | colorectal carcinoma |
| E_00296 | chr8:128231146-128231713 | Pancreatic islet | pancreatic beta cell | -- |
Expression of Target Genes for the Enhancer