About Enhancer
| Enhancer ID: | E_00298 |
| Species: | Homo sapiens |
| Position : | chr3:123065517-123065936   |
| Year: | 2017 |
| Title: | Type 2 Diabetes enhancer at ADCY5 |
| Genome Build: | hg19 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | colorectal cancer |
| PMID: | 28684635 |
| MONDO: | MONDO:0005176 |
| Tissue: | Colon |
| Tissue Ontology ID: | UBERON:0001155 |
| Cell Source: | HT29 |
| CVCL ID: | CVCL_0320 |
| Cell Type: | colorectal carcinoma cell |
| Cell Ontology ID: | CL:0000066 |
| Experiment Type: | Enhancer activity assay, Functional perturbation assay |
| High Throughput Method: | ChIP-seq, ATAC-seq |
| Low Throughput Method: | Luciferase Reporter Assay, EMSA, CRISPR Knockout, RT-RT-qPCR |
About Target Gene
| Target gene : | ADCY5 |
About TF
| TF name : | NKX2-2 |
About Regulatory State
| Regulatory State : | Silenced |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| NKX2-2 | Regulation of gene expression in beta cells | reactome | 17 |
| NKX2-2 | Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells | reactome | 5 |
| NKX2-2 | Maturity onset diabetes of the young | kegg | 25 |
| NKX2-2 | Hs_Dopaminergic_Neurogenesis_WP2855_87239 | wikipathways | 19 |
Enhancer Associated Network
Overlapping Enhancers (hg19)
No overlapping enhancers found in hg19 at this locus.
Expression of Target Genes for the Enhancer