About Enhancer
| Enhancer ID: | E_00313 |
| Species: | Homo sapiens |
| Position : | chr22:39666991-39667170   |
| Year: | 2023 |
| Title: | Interactive enhancer hubs (iHUBs) mediate transcriptional reprogramming and adaptive resistance in pancreatic cancer |
| Genome Build: | hg19 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | pancreatic ductal adenocarcinoma |
| PMID: | 36889906 |
| MONDO: | MONDO:0005147 |
| Tissue: | Pancreas |
| Tissue Ontology ID: | UBERON:0001264 |
| Cell Source: | L3.6pl |
| CVCL ID: | CVCL_0384 |
| Cell Type: | pancreatic ductal adenocarcinoma cell |
| Cell Ontology ID: | CL:0000066 |
| Experiment Type: | Enhancer activity assay, Chromatin interaction assay, Functional perturbation assay |
| High Throughput Method: | ChIP-seq, ATAC-seq, HiChIP, leChRO-seq |
| Low Throughput Method: | CRISPR knockout, 4C-seq, RT-RT-qPCR |
About Target Gene
| Target gene : | LIF |
About TF
| TF name : | JUND |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| JUND | AP-1 transcription factor network | pid | 71 |
| JUND | ATF-2 transcription factor network | pid | 59 |
| JUND | EGFR1 | netpath | 475 |
| JUND | Inflammation mediated by chemokine and cytokine signaling pathway | panther | 189 |
| JUND | PDGFR-beta signaling pathway | pid | 125 |
| JUND | TGF-beta signaling pathway | panther | 88 |
| JUND | TGF_beta_Receptor | netpath | 220 |
| JUND | Validated transcriptional targets of AP1 family members Fra1 and Fra2 | pid | 37 |
| JUND | MAPK signaling pathway | kegg | 264 |
| JUND | Hs_Apoptosis-related_network_due_to_altered_Notch3_in_ovarian_cancer_WP2864_79278 | wikipathways | 51 |
| JUND | Hs_VEGFA-VEGFR2_Signaling_Pathway_WP3888_90000 | wikipathways | 153 |
| JUND | Hs_Oncostatin_M_Signaling_Pathway_WP2374_73668 | wikipathways | 44 |
| JUND | Hs_EGF-EGFR_Signaling_Pathway_WP437_79266 | wikipathways | 107 |
Enhancer Associated Network
Overlapping Enhancers (hg19)
1 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_00314 | chr22:39666991-39667170 | Pancreas | pancreatic ductal adenocarcinoma cell | pancreatic ductal adenocarcinoma |
Expression of Target Genes for the Enhancer