About Enhancer
| Enhancer ID: | E_00322 |
| Species: | Homo sapiens |
| Position : | chr12:115092472-115096258   |
| Year: | 2026 |
| Title: | The castration resistant prostate cancer associated SNP rs11067228 facilitates neuroendocrine differentiation through an enhancer mediated chromatin interaction with SRRM4 |
| Genome Build: | hg19 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | T-cell acute lymphoblastic leukemia |
| PMID: | 39428991 |
| MONDO: | MONDO:0004947 |
| Tissue: | Blood |
| Tissue Ontology ID: | UBERON:0000178 |
| Cell Source: | Jurkat |
| CVCL ID: | CVCL_0065 |
| Cell Type: | T lymphoblast |
| Cell Ontology ID: | CL:0002419 |
| Experiment Type: | Chromatin interaction assay |
| High Throughput Method: | ChIP-seq, 4C-seq |
| Low Throughput Method: | CRISPR knockout |
About Target Gene
| Target gene : | SRRM4 |
About TF
| TF name : | SOX4 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| SOX4 | Deactivation of the beta-catenin transactivating complex | reactome | 42 |
| SOX4 | IL5 | netpath | 59 |
Enhancer Associated Network
Overlapping Enhancers (hg19)
No overlapping enhancers found in hg19 at this locus.
Expression of Target Genes for the Enhancer