About Enhancer
| Enhancer ID: | E_00325 |
| Species: | Homo sapiens |
| Position : | chr8:130180217-130180629   |
| Year: | 2014 |
| Title: | Long-range enhancer activity determines Myc sensitivity to Notch inhibitors in T cell leukemia |
| Genome Build: | hg19 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | adult T-cell leukemia/lymphoma |
| PMID: | 25369933 |
| MONDO: | MONDO:0005026 |
| Tissue: | Peripheral Blood |
| Tissue Ontology ID: | UBERON:0000178 |
| Cell Source: | Primary ATL cells |
| CVCL ID: | |
| Cell Type: | T cell |
| Cell Ontology ID: | CL:0000084 |
| Experiment Type: | Enhancer activity assay, Chromatin interaction assay, TF binding assay, Functional perturbation assay |
| High Throughput Method: | ChIP-seq |
| Low Throughput Method: | Luciferase Reporter Assay, 3C, ChIP-RT-qPCR, RT-RT-qPCR |
About Target Gene
| Target gene : | MYC |
About TF
| TF name : | NOTCH1; RBPJ |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|
Enhancer Associated Network
Overlapping Enhancers (hg19)
3 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_01253 | chr8:130180000-130181000 | Blood | T lymphoblast | T-cell acute lymphoblastic leukemia |
| E_01254 | chr8:130180000-130181000 | Blood | T lymphoblast | T-cell acute lymphoblastic leukemia |
| E_00452 | chr8:130180065-130180972 | Blood | T lymphoblast | T-cell acute lymphoblastic leukemia |
Expression of Target Genes for the Enhancer