About Enhancer
| Enhancer ID: | E_00332 |
| Species: | Homo sapiens |
| Position : | chr11:5301549-5302549   |
| Year: | 2020 |
| Title: | Interrogation of enhancer function by enhancer-targeting CRISPR epigenetic editing |
| Genome Build: | hg19 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | chronic myeloid leukemia |
| PMID: | 31980609 |
| MONDO: | MONDO:0011998 |
| Tissue: | Blood |
| Tissue Ontology ID: | UBERON:0000178 |
| Cell Source: | K562 erythroleukemia |
| CVCL ID: | CVCL_0004 |
| Cell Type: | chronic myeloid leukemia cell |
| Cell Ontology ID: | CL:0001054 |
| Experiment Type: | Enhancer activity assay, Functional perturbation assay, TF binding assay |
| High Throughput Method: | ChIP-seq, RNA-seq, ATAC-seq |
| Low Throughput Method: | CRISPRi, CRISPRa, RT-RT-qPCR, Western blot |
About Target Gene
| Target gene : | HBE1 |
About TF
| TF name : | GATA1 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| GATA1 | C-MYB transcription factor network | pid | 87 |
| GATA1 | Factors involved in megakaryocyte development and platelet production | reactome | 111 |
| GATA1 | IL3 | netpath | 84 |
| GATA1 | Notch-mediated HES/HEY network | pid | 48 |
| GATA1 | p73 transcription factor network | pid | 80 |
| GATA1 | Signaling events mediated by HDAC Class I | pid | 89 |
| GATA1 | Signaling events mediated by HDAC Class II | pid | 58 |
Enhancer Associated Network
Overlapping Enhancers (hg19)
4 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_00234 | chr11:5301549-5302549 | Liver | hepatocellular carcinoma cell | hepatocellular carcinoma |
| E_00321 | chr11:5301549-5302549 | Blood | chronic myeloid leukemia cell | chronic myeloid leukemia |
| E_00323 | chr11:5301549-5302549 | Peripheral Blood | T cell | adult T-cell leukemia/lymphoma |
| E_00340 | chr11:5301862-5302715 | Hematopoietic system | chronic myeloid leukemia cell | chronic myeloid leukemia |
Expression of Target Genes for the Enhancer