About Enhancer
| Enhancer ID: | E_00340 |
| Species: | Homo sapiens |
| Position : | chr11:5301862-5302715   |
| Year: | 2015 |
| Title: | Highly specific epigenome editing by CRISPR-Cas9 repressors for silencing of distal regulatory elements |
| Genome Build: | hg19 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | chronic myeloid leukemia |
| PMID: | 26501517 |
| MONDO: | MONDO:0011998 |
| Tissue: | Hematopoietic system |
| Tissue Ontology ID: | UBERON:0002371 |
| Cell Source: | K562 |
| CVCL ID: | CVCL_0004 |
| Cell Type: | chronic myeloid leukemia cell |
| Cell Ontology ID: | CL:0001054 |
| Experiment Type: | Functional perturbation assay |
| High Throughput Method: | ChIP-seq, RNA-seq |
| Low Throughput Method: | CRISPR Knockout, ChIP-RT-qPCR, RT-RT-qPCR |
About Target Gene
| Target gene : | HBG1 |
About TF
| TF name : | GATA2 |
About Regulatory State
| Regulatory State : | Silenced |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| GATA2 | AP-1 transcription factor network | pid | 71 |
| GATA2 | Factors involved in megakaryocyte development and platelet production | reactome | 111 |
| GATA2 | HIF-1-alpha transcription factor network | pid | 67 |
| GATA2 | IL3 | netpath | 84 |
| GATA2 | Regulation of Androgen receptor activity | pid | 54 |
| GATA2 | Signaling events mediated by HDAC Class I | pid | 89 |
| GATA2 | Signaling events mediated by HDAC Class II | pid | 58 |
| GATA2 | Hs_Apoptosis_WP254_88977 | wikipathways | 31 |
Enhancer Associated Network
Overlapping Enhancers (hg19)
4 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_00234 | chr11:5301549-5302549 | Liver | hepatocellular carcinoma cell | hepatocellular carcinoma |
| E_00321 | chr11:5301549-5302549 | Blood | chronic myeloid leukemia cell | chronic myeloid leukemia |
| E_00323 | chr11:5301549-5302549 | Peripheral Blood | T cell | adult T-cell leukemia/lymphoma |
| E_00332 | chr11:5301549-5302549 | Blood | chronic myeloid leukemia cell | chronic myeloid leukemia |
Expression of Target Genes for the Enhancer