Enhancer Detail

Comprehensive information about experimentally validated enhancers

About Enhancer
Enhancer ID: E_00343
Species: Mus musculus
Position : chr12:85475057-85477322
Year: 2016
Title: Stimulus-specific combinatorial functionality of neuronal c-fos enhancers.
Genome Build: mm10
Enhancer Type: Enhancer
Condition: Normal
PMID:  26595656
Tissue: brain
Tissue Ontology ID: UBERON:0000955
Cell Source: primary mouse cortical neurons
Cell Type: neuron
Cell Ontology ID: CL:0000540
Experiment Type: Stimulus-responsive enhancer assay; endogenous enhancer perturbation
High Throughput Method: RNA-seq; ChIP-seq and chromatin-state integration
Low Throughput Method: Luciferase reporter assay; enhancer RNA RT-qPCR; CRISPRi; NPAS4 binding and transcription-factor perturbation
About Target Gene
Target gene : Fos
About TF
TF name : Npas4
About Regulatory State
Regulatory State : Active
Upstream Pathway Annotation of TF
GeneName Pathway Name Source Gene Number
Enhancer Associated Network
Overlapping Enhancers (mm10) 2 found
Enhancer ID Position Tissue Cell Disease
E_00342 chr12:85475057-85477322 brain neuron NA
E_00458 chr12:85475057-85477322 cerebral cortex neuron NA
Expression of Target Genes for the Enhancer