About Enhancer
| Enhancer ID: | E_00354 |
| Species: | Homo sapiens |
| Position : | chr2:74404247-74404647   |
| Year: | 2022 |
| Title: | Discovery and Functional Characterization of Two Regulatory Variants Underlying Lupus Susceptibility at 2p131 |
| Genome Build: | hg19 |
| Enhancer Type: | Enhancer |
| Condition: | Normal |
| Disease Name: | -- |
| PMID: | 35741778 |
| MONDO: | |
| Tissue: | Blood |
| Tissue Ontology ID: | UBERON:0000178 |
| Cell Source: | GM12878 |
| CVCL ID: | CVCL_7526 |
| Cell Type: | B lymphoblastoid cell |
| Cell Ontology ID: | CL:0000945 |
| Experiment Type: | Enhancer activity assay, TF binding assay |
| High Throughput Method: | ChIP-seq, Hi-C, RNA-seq |
| Low Throughput Method: | Luciferase Reporter Assay, ChIP-RT-qPCR, qRT-PCR, Western blot |
About Target Gene
| Target gene : | DGUOK |
About TF
| TF name : | ARID3A |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| ARID3A | Direct p53 effectors | pid | 141 |
| ARID3A | TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest | reactome | 13 |
Enhancer Associated Network
Overlapping Enhancers (hg19)
No overlapping enhancers found in hg19 at this locus.
Expression of Target Genes for the Enhancer