About Enhancer
| Enhancer ID: | E_00357 |
| Species: | Homo sapiens |
| Position : | chr17:48110000-48150000   |
| Year: | 2024 |
| Title: | Differential histone acetylation and super-enhancer regulation underlie melanoma cell dedifferentiation |
| Genome Build: | hg19 |
| Enhancer Type: | Super-enhancer |
| Condition: | Disease |
| Disease Name: | skin melanoma |
| PMID: | 38319712 |
| MONDO: | MONDO:0005105 |
| Tissue: | Skin |
| Tissue Ontology ID: | UBERON:0000014 |
| Cell Source: | A375 |
| CVCL ID: | CVCL_0132 |
| Cell Type: | melanoma cell |
| Cell Ontology ID: | CL:0002573 |
| Experiment Type: | TF binding assay, Enhancer activity assay, Functional perturbation assay |
| High Throughput Method: | ChIP-seq, RNA-seq, ATAC-seq |
| Low Throughput Method: | CRISPR Knockout, qRT-PCR, Western blot |
About Target Gene
| Target gene : | ITGA3 |
About TF
| TF name : | JUNB |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| JUNB | AP-1 transcription factor network | pid | 71 |
| JUNB | ATF-2 transcription factor network | pid | 59 |
| JUNB | BCR | netpath | 161 |
| JUNB | Calcineurin-regulated NFAT-dependent transcription in lymphocytes | pid | 50 |
| JUNB | Calcium signaling in the CD4+ TCR pathway | pid | 29 |
| JUNB | Downstream signaling in naïve CD8+ T cells | pid | 69 |
| JUNB | IL6-mediated signaling events | pid | 48 |
| JUNB | Inflammation mediated by chemokine and cytokine signaling pathway | panther | 189 |
| JUNB | SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription | reactome | 32 |
| JUNB | TGF-beta signaling pathway | panther | 88 |
| JUNB | TGF_beta_Receptor | netpath | 220 |
| JUNB | TNFalpha | netpath | 274 |
| JUNB | Validated transcriptional targets of AP1 family members Fra1 and Fra2 | pid | 37 |
| JUNB | Hs_Kit_receptor_signaling_pathway_WP304_78799 | wikipathways | 46 |
| JUNB | Hs_TGF-beta_Signaling_Pathway_WP366_90028 | wikipathways | 67 |
Enhancer Associated Network
Expression of Target Genes for the Enhancer