About Enhancer
| Enhancer ID: | E_00359 |
| Species: | Mus musculus |
| Position : | chr12:85466416-85469570   |
| Year: | 2016 |
| Title: | Stimulus-specific combinatorial functionality of neuronal c-fos enhancers. |
| Genome Build: | mm10 |
| Enhancer Type: | Enhancer |
| Condition: | Normal |
| PMID: | 26595656 |
| Tissue: | brain |
| Tissue Ontology ID: | UBERON:0000955 |
| Cell Source: | Mouse Cortical Neurons |
| Experiment Type: | Enhancer activity assay; TF-binding/chromatin assay; Chromatin interaction assay; Endogenous enhancer perturbation; Genetic-variant functional analysis |
| High Throughput Method: | ChIP-seq |
| Low Throughput Method: | Luciferase reporter assay; Reporter assay; CRISPR-Cas9 targeted editing/deletion; ChIP-qPCR/ChIP; 3C; RT-qPCR/qPCR |
About Target Gene
| Target gene : | Fos |
About TF
| TF name : | Mef2d |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| Mef2d | CDO in myogenesis | reactome | 29 |
| Mef2d | Circadian Clock | reactome | 49 |
| Mef2d | p38 MAPK pathway | panther | 31 |
| Mef2d | Role of Calcineurin-dependent NFAT signaling in lymphocytes | pid | 54 |
| Mef2d | Signaling events mediated by HDAC Class III | pid | 41 |
| Mef2d | Transcriptional activation of mitochondrial biogenesis | reactome | 43 |
Enhancer Associated Network
Overlapping Enhancers (mm10)
8 found
| Enhancer ID | Position | Tissue | Cell | Disease |
|---|---|---|---|---|
| E_00064 | chr12:85463935-85468299 | brain | neuron | NA |
| E_00065 | chr12:85463935-85468299 | brain | neuron | NA |
| E_00379 | chr12:85463935-85468299 | cerebral cortex | neuron | NA |
| E_00356 | chr12:85466416-85469570 | brain | NA | NA |
| E_00357 | chr12:85466416-85469570 | brain | NA | NA |
| E_00358 | chr12:85466416-85469570 | brain | NA | NA |
| E_00360 | chr12:85466416-85469570 | brain | NA | NA |
| E_00361 | chr12:85466416-85469570 | brain | NA | NA |
Expression of Target Genes for the Enhancer