About Enhancer
| Enhancer ID: | E_00360 |
| Species: | Homo sapiens |
| Position : | chr17:79780000-79828000   |
| Year: | 2022 |
| Title: | Super-enhancer hijacking LINC01977 promotes malignancy of early-stage lung adenocarcinoma addicted to the canonical TGF-??/SMAD3 pathway |
| Genome Build: | hg19 |
| Enhancer Type: | Enhancer |
| Condition: | Disease |
| Disease Name: | lung adenocarcinoma |
| PMID: | 35982471 |
| MONDO: | MONDO:0005032 |
| Tissue: | Lung |
| Tissue Ontology ID: | UBERON:0002048 |
| Cell Source: | A549 |
| CVCL ID: | CVCL_0023 |
| Cell Type: | lung adenocarcinoma cell |
| Cell Ontology ID: | CL:0001069 |
| Experiment Type: | Enhancer activity assay, TF binding assay, Chromatin interaction assay, Functional perturbation assay |
| High Throughput Method: | ChIP-seq, Hi-C, RNA-seq |
| Low Throughput Method: | Luciferase Reporter Assay, ChIP-RT-qPCR, RT-RT-qPCR, Western blot |
About Target Gene
| Target gene : | LINC01977 |
About TF
| TF name : | SMAD3; CBP; EP300 |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|
Enhancer Associated Network
Expression of Target Genes for the Enhancer