About Enhancer
| Enhancer ID: | E_00367 |
| Species: | Mus musculus |
| Position : | chr12:85470646-85474086   |
| Year: | 2016 |
| Title: | Stimulus-specific combinatorial functionality of neuronal c-fos enhancers. |
| Genome Build: | mm10 |
| Enhancer Type: | Enhancer |
| Condition: | Normal |
| PMID: | 26595656 |
| Tissue: | brain |
| Tissue Ontology ID: | UBERON:0000955 |
| Cell Source: | Mouse Cortical Neurons |
| Experiment Type: | Enhancer activity assay; TF-binding/chromatin assay; Chromatin interaction assay; Endogenous enhancer perturbation; Genetic-variant functional analysis |
| High Throughput Method: | ChIP-seq |
| Low Throughput Method: | Luciferase reporter assay; Reporter assay; CRISPR-Cas9 targeted editing/deletion; ChIP-qPCR/ChIP; 3C; RT-qPCR/qPCR |
About Target Gene
| Target gene : | Fos |
About TF
| TF name : | Srf |
About Regulatory State
| Regulatory State : | Active |
Upstream Pathway Annotation of TF
| GeneName | Pathway Name | Source | Gene Number |
|---|---|---|---|
| Srf | Coregulation of Androgen receptor activity | pid | 61 |
| Srf | ErbB1 downstream signaling | pid | 105 |
| Srf | Interleukin signaling pathway | panther | 86 |
| Srf | p38 MAPK pathway | panther | 31 |
| Srf | p38 signaling mediated by MAPKAP kinases | pid | 21 |
| Srf | PDGF signaling pathway | panther | 113 |
| Srf | PDGFR-alpha signaling pathway | pid | 22 |
| Srf | PDGFR-beta signaling pathway | pid | 125 |
| Srf | Ras Pathway | panther | 69 |
| Srf | RHO GTPases Activate Formins | reactome | 114 |
| Srf | RhoA signaling pathway | pid | 46 |
| Srf | Signaling events mediated by HDAC Class II | pid | 58 |
| Srf | Trk receptor signaling mediated by the MAPK pathway | pid | 34 |
| Srf | MAPK signaling pathway | kegg | 264 |
| Srf | Hs_VEGFA-VEGFR2_Signaling_Pathway_WP3888_90000 | wikipathways | 153 |
| Srf | Hs_Serotonin_Receptor_4-6-7_and_NR3C_Signaling_WP734_74438 | wikipathways | 15 |
| Srf | Hs_Mesodermal_Commitment_Pathway_WP2857_87780 | wikipathways | 47 |
| Srf | Hs_Serotonin_Receptor_2_and_ELK-SRF-GATA4_signaling_WP732_80010 | wikipathways | 13 |
Enhancer Associated Network
Expression of Target Genes for the Enhancer